Growth characteristics underlying retrogenia in pigs: A histomorphometric study
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The Ohio State University / OhioLINK
2014
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=osu1395925724 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-osu13959257242021-08-03T06:23:05Z Growth characteristics underlying retrogenia in pigs: A histomorphometric study Price, Jeff Cellular Biology Dentistry Objectives: To establish an animal model for studying human retrogenia, this project characterized bone modeling activities at the symphyseal surfaces of juvenile pigs which normally lack chin projections. Material and Methods: Ten domestic pigs of two age groups (4- and 6-month-old) were included. Their symphyseal specimens were processed into histological sections with and without decalcification, which were assessed for surface mineral apposition and bone resorption, respectively. In a blinded fashion, measurements of four parameters (MAR: mineral apposition rate, MAZ: mineral apposition zone; CI: concavity index; OI: osteoclast index) were obtained and tested by a multivariate two-way mixed model analyses of variance (MANOVA) for the differences between different symphyseal regions and ages. Results: Qualitatively, the labial and lingual surfaces were characterized by abundant mineral apposition and bone resorption, respectively. Quantitatively, measurements of the labial surface mineral apposition showed an interaction between the region and age factor (for MAR, p=0.127; for MAZ, p=0.012), indicating increase of mineral apposition with age at the inferior region. Measurements of bone resorption of the lingual surface showed the inferior-lingual region tended to have stronger resorption than the superior-lingual region (region*age interaction for OI, p=0.087; regional difference for CI, p= p=0.025). Conclusion: A possible explanation for retrogenia in pigs is that the entire labial surface is appositional and the growth differential between the superior and inferior labial regions is inadequate for developing a chin projection. The pig may be used as a reasonable animal model to study growth modification approaches for human retrogenia. 2014-06-06 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1395925724 http://rave.ohiolink.edu/etdc/view?acc_num=osu1395925724 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Cellular Biology Dentistry |
| spellingShingle |
Cellular Biology Dentistry Price, Jeff Growth characteristics underlying retrogenia in pigs: A histomorphometric study |
| author |
Price, Jeff |
| author_facet |
Price, Jeff |
| author_sort |
Price, Jeff |
| title |
Growth characteristics underlying retrogenia in pigs: A histomorphometric study |
| title_short |
Growth characteristics underlying retrogenia in pigs: A histomorphometric study |
| title_full |
Growth characteristics underlying retrogenia in pigs: A histomorphometric study |
| title_fullStr |
Growth characteristics underlying retrogenia in pigs: A histomorphometric study |
| title_full_unstemmed |
Growth characteristics underlying retrogenia in pigs: A histomorphometric study |
| title_sort |
growth characteristics underlying retrogenia in pigs: a histomorphometric study |
| publisher |
The Ohio State University / OhioLINK |
| publishDate |
2014 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1395925724 |
| work_keys_str_mv |
AT pricejeff growthcharacteristicsunderlyingretrogeniainpigsahistomorphometricstudy |
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1719435932500754432 |