CD31: Invasive Predictive Biomarker for Malignant Transformation of Oral Epithelial Dysplasia
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The Ohio State University / OhioLINK
2013
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=osu1376839992 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-osu13768399922021-08-03T06:19:24Z CD31: Invasive Predictive Biomarker for Malignant Transformation of Oral Epithelial Dysplasia Hagen, Jeffrey M. Dentistry While not all oral epithelial dysplasia (OED) lesions will transform, approximately one third of OED lesions progress to oral squamous cell carcinoma (OSCC). Provided the poor overall prognosis for OSCC patients, intervention at the premalignant stage of OED is an attractive clinical strategy. We do not, however, currently have biomarkers to identify the most aggressive premalignant lesions. Identification of such biological indicators would allow for targeting of OED lesions with high transformation risk and direct lesional-specific management e.g. anti-angiogenic compounds. A wealth of translational and clinical research supports the key role of angiogenesis during malignant transformation. Past human studies involving pre-neoplastic lesions of breast and cervical tissue have revealed a positive correlation between angiogenesis and the progression, prognosis and metastasis of ductal carcinoma in situ and cervical intraepithelial neoplasia. In addition to studies involving human breast and cervical tissue, numerous studies have been carried out to examine the association of between angiogenesis and progression of OED. These data present compelling evidence regarding MVD’s importance in carcinogenesis. A site-matched longitudinal assessment was conducted to determine if increased microvascular density positively correlates with malignant transformation. The clinical basis of this current study: i) identifiy oral epithelial dysplastic lesions likely to progress to OSCC, thus, dictating a more aggressive treatment modality and ii) establish reliable clinically relevant biomarkers for OSCC chemoprevention. 2013 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1376839992 http://rave.ohiolink.edu/etdc/view?acc_num=osu1376839992 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Dentistry |
| spellingShingle |
Dentistry Hagen, Jeffrey M. CD31: Invasive Predictive Biomarker for Malignant Transformation of Oral Epithelial Dysplasia |
| author |
Hagen, Jeffrey M. |
| author_facet |
Hagen, Jeffrey M. |
| author_sort |
Hagen, Jeffrey M. |
| title |
CD31: Invasive Predictive Biomarker for Malignant Transformation of Oral Epithelial Dysplasia |
| title_short |
CD31: Invasive Predictive Biomarker for Malignant Transformation of Oral Epithelial Dysplasia |
| title_full |
CD31: Invasive Predictive Biomarker for Malignant Transformation of Oral Epithelial Dysplasia |
| title_fullStr |
CD31: Invasive Predictive Biomarker for Malignant Transformation of Oral Epithelial Dysplasia |
| title_full_unstemmed |
CD31: Invasive Predictive Biomarker for Malignant Transformation of Oral Epithelial Dysplasia |
| title_sort |
cd31: invasive predictive biomarker for malignant transformation of oral epithelial dysplasia |
| publisher |
The Ohio State University / OhioLINK |
| publishDate |
2013 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1376839992 |
| work_keys_str_mv |
AT hagenjeffreym cd31invasivepredictivebiomarkerformalignanttransformationoforalepithelialdysplasia |
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1719434676018348032 |