Patterned Magnetic Structures for Micro-/Nanoparticle and Cell Manipulation
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The Ohio State University / OhioLINK
2012
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=osu1354567338 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-osu13545673382021-08-03T06:06:46Z Patterned Magnetic Structures for Micro-/Nanoparticle and Cell Manipulation Vieira, Gregory Butler Physics Patterned Magnetic Structures Microparticles Nanoparticles Particle Trapping and Manipulation Cell Trapping Domain Walls <p>Remote manipulation of fluid-borne magnetic particles on a surface is useful to probe, assemble, and sort microscale and nanoscale objects. By patterning magnetic structures in shapes designed to exploit local heterogeneities in thin film magnetization, we have demonstrated effective trapping mechanisms for superparamagnetic micro- and nanoparticles. The features necessary for trapping are shown to arise at domain walls or indentations in microscale and smaller magnetic wires, at the periphery of magnetized disks, and at corners of magnetized triangles.</p><p>Weak (<150 Oe) in- and out-of-plane external magnetic fields modify the energy landscape of the trapped particles, allowing for the objects to be remotely maneuvered along selected routes across the surface. The mechanism is multiplexed, allowing for simultaneous manipulation of many trapped particles, and their motion is directed using a handheld user interface. Particles are able to be transported over hundreds of micrometers with velocities of upwards of 200 μm/s and average forces of up to hundreds of picoNewtons.</p><p>The magnetic fields, their spatial distribution, and resulting forces are estimated by modeling magnetization of the patterned structures using micromagnetic simulation or by approximating the traps as point sources of fields. The quality of these models and their relevance for describing particle manipulation under the experimental conditions is discussed.</p><p>The applicability of these techniques is demonstrated for various biological, biomolecular, and nanoscale systems. Binding of magnetic particles to cells allows for guided cell transport. Composite micelle nanostructures, only tens of nm across, are simultaneously trapped and maneuvered magnetically and tracked fluorescently, despite their small size. The implications for use of this technology in lab-on-chip devices are discussed.</p> 2012-12-19 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1354567338 http://rave.ohiolink.edu/etdc/view?acc_num=osu1354567338 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Physics Patterned Magnetic Structures Microparticles Nanoparticles Particle Trapping and Manipulation Cell Trapping Domain Walls |
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Physics Patterned Magnetic Structures Microparticles Nanoparticles Particle Trapping and Manipulation Cell Trapping Domain Walls Vieira, Gregory Butler Patterned Magnetic Structures for Micro-/Nanoparticle and Cell Manipulation |
| author |
Vieira, Gregory Butler |
| author_facet |
Vieira, Gregory Butler |
| author_sort |
Vieira, Gregory Butler |
| title |
Patterned Magnetic Structures for Micro-/Nanoparticle and Cell Manipulation |
| title_short |
Patterned Magnetic Structures for Micro-/Nanoparticle and Cell Manipulation |
| title_full |
Patterned Magnetic Structures for Micro-/Nanoparticle and Cell Manipulation |
| title_fullStr |
Patterned Magnetic Structures for Micro-/Nanoparticle and Cell Manipulation |
| title_full_unstemmed |
Patterned Magnetic Structures for Micro-/Nanoparticle and Cell Manipulation |
| title_sort |
patterned magnetic structures for micro-/nanoparticle and cell manipulation |
| publisher |
The Ohio State University / OhioLINK |
| publishDate |
2012 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1354567338 |
| work_keys_str_mv |
AT vieiragregorybutler patternedmagneticstructuresformicronanoparticleandcellmanipulation |
| _version_ |
1719431106436005888 |