Atrial Structure and Function in Non-ischemic Heart Failure
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2012
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ndltd-OhioLink-oai-etd.ohiolink.edu-osu13539757282021-08-03T06:06:46Z Atrial Structure and Function in Non-ischemic Heart Failure Vargas-Pinto, Pedro Alexis Biomedical Research tachycardia-induced Heart failure atrial function P wave. For years researchers have looked for the perfect model to study heart failure (HF), and thereby understand its mechanistic causes and consequences. Among those models, there is one, rapid pacing, that has been used for decades because it recreates the process in weeks to months, as happens in human beings. Rapid pacing has answered several questions on mechanisms of cardiac remodeling during heart failure and how the body responds to it in terms of changes in hormones and proinflammatory mediators. In this study I established in a non-invasive manner the effect of time-dependent effects of heart failure on atrial depolarization time and how this is associated with atrial size and function (structural remodeling). At the in vitro level we examined the qualitative and quantitative effects of HF on atrial connexin 43. Atrial functional and structural remodeling during HF, contributes to the generation and maintenance of the most common sustained arrhythmia found in human beings, atrial fibrillation.In this study, HF caused electrophysiological remodeling (properties of the P wave), structural remodeling (LA enlargement), and dynamic functional remodeling (tardy contraction of the caudal portion of the LA). These findings closely mimic observations made in human patients at risk for atrial fibrillation. 2012-12-18 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1353975728 http://rave.ohiolink.edu/etdc/view?acc_num=osu1353975728 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biomedical Research tachycardia-induced Heart failure atrial function P wave. |
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Biomedical Research tachycardia-induced Heart failure atrial function P wave. Vargas-Pinto, Pedro Alexis Atrial Structure and Function in Non-ischemic Heart Failure |
| author |
Vargas-Pinto, Pedro Alexis |
| author_facet |
Vargas-Pinto, Pedro Alexis |
| author_sort |
Vargas-Pinto, Pedro Alexis |
| title |
Atrial Structure and Function in Non-ischemic Heart Failure |
| title_short |
Atrial Structure and Function in Non-ischemic Heart Failure |
| title_full |
Atrial Structure and Function in Non-ischemic Heart Failure |
| title_fullStr |
Atrial Structure and Function in Non-ischemic Heart Failure |
| title_full_unstemmed |
Atrial Structure and Function in Non-ischemic Heart Failure |
| title_sort |
atrial structure and function in non-ischemic heart failure |
| publisher |
The Ohio State University / OhioLINK |
| publishDate |
2012 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1353975728 |
| work_keys_str_mv |
AT vargaspintopedroalexis atrialstructureandfunctioninnonischemicheartfailure |
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1719431079422590976 |