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ndltd-OhioLink-oai-etd.ohiolink.edu-osu1339717205
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oai_dc
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ndltd-OhioLink-oai-etd.ohiolink.edu-osu13397172052021-08-03T06:05:34Z Detecting Gene Modules Differentially Expressed in Multiple Human Brain Regions Ma, Zhiwei Molecular screen methods such as microarrays have been used to identify molecular signatures and biological processes important for particular neuronal functions. This thesis applied a weight gene co-expression network analysis algorithm, edge-covering Quasi-Clique Merger algorithm (eQCM), on human brain microarray data from the Allen Institute of Brain Science. One thousand and sixty-six (1066) gene modules were identified. Within these 1066 gene modules, using eigengene as the representation of each gene module, 46 gene modules with significant p-values were selected by comparing the gene expression profiles between the hippocampus, parahippocampal gyrus and basal ganglia in the human brain. Through gene ontology enrichment analysis, 10 out of these 46 gene modules are significantly engaged in several biological processes of neuronal functions. The results showed that the correlation between molecular similarities and spatial proximity still exists in some human brain regions other than the neocortex. 2012-06-26 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1339717205 http://rave.ohiolink.edu/etdc/view?acc_num=osu1339717205 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
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NDLTD
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| language |
English
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NDLTD
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| author |
Ma, Zhiwei
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| spellingShingle |
Ma, Zhiwei
Detecting Gene Modules Differentially Expressed in Multiple Human Brain Regions
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| author_facet |
Ma, Zhiwei
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| author_sort |
Ma, Zhiwei
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| title |
Detecting Gene Modules Differentially Expressed in Multiple Human Brain Regions
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| title_short |
Detecting Gene Modules Differentially Expressed in Multiple Human Brain Regions
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| title_full |
Detecting Gene Modules Differentially Expressed in Multiple Human Brain Regions
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| title_fullStr |
Detecting Gene Modules Differentially Expressed in Multiple Human Brain Regions
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| title_full_unstemmed |
Detecting Gene Modules Differentially Expressed in Multiple Human Brain Regions
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| title_sort |
detecting gene modules differentially expressed in multiple human brain regions
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| publisher |
The Ohio State University / OhioLINK
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| publishDate |
2012
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| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1339717205
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AT mazhiwei detectinggenemodulesdifferentiallyexpressedinmultiplehumanbrainregions
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1719430782233083904
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