SITE-SPECIFIC CHARACTERISTICS OF PERI-IMPLANT WOUND

Bibliographic Details
Main Author:	Lee, Connie
Language:	English
Published:	The Ohio State University / OhioLINK 2012
Subjects:	Dentistry peri-implant wound healing cytokines crevicular fluid RFA
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=osu1338117117

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-osu13381171172021-08-03T06:05:17Z SITE-SPECIFIC CHARACTERISTICS OF PERI-IMPLANT WOUND Lee, Connie Dentistry peri-implant wound healing cytokines crevicular fluid RFA <p>Objective: One-stage implant placement allows evaluation of early healing. This study aims to determine site-specific characteristics of peri-implant wounds. </p><p>Material and Methods: Bone level implants in non-smoker patients were simultaneously placed at two posterior quadrants. Resonance Frequency Analysis (RFA) was performed at placement and 4 weeks post-operatively. Bone plate and flap thicknesses were measured with a caliper. Plaque and gingival indices (PI and GI) and probing depth (PD) were determined at baseline and during healing. Crevicular fluid (CF) was collected using sterile strips. Gingival tissue biopsies were obtained for future studies. CF was processed through multiplex assays for several cytokines associated with wound healing. Repeated Measures ANOVA followed by Bonferroni adjustment and Spearman Correlation Coefficient were conducted.</p><p>Results: Of twenty-seven subjects that were recruited, twenty-two patients (13 female; 55±3yrs) completed the study. Surgical site A and B were assigned at the first post-operative appointment. Initial bone and flap thicknesses were similar between surgical sites (P>0.05). Probing depth ranged 2.5 to 3.2 mm, with statistically deeper peri-implant PD than periodontal PD at both sites during 4th week (P<0.03). RFA revealed an initial 69±1.3 ISQ for site A, compared to 73±1.14 ISQ for site B (P=0.03), which changed to 71±1.4 and 69±2.4 ISQ at 4 weeks, respectively. There was no statistically significant difference between baseline and 4 weeks at both sites, and between sites at 4 weeks (P>0.05). PI and GI decreased at both sites by 4th week (P>0.05). Initial CF volume increase at week 1 diminished to baseline levels by week 4, with significant difference within site A at week 1 and 4 (P=0.002), and between site A and B for peri-implant CF at week 1 (P=0.05). Statistically significant differences were detected for IL-1ra expression within site A between gingival (GCF) and peri-implant crevicular fluid (PICF) levels at 1 week (P=0.002) and 4 weeks (P=0.004), and within site B between GCF and PICF levels at 4 week (P=0.002). IL-6 expression also showed significant differences within site A at GCF level between 1 and 4 weeks (P=0.002), and within site B between GCF and PICF levels at 1 week (P=0.02). Lastly, MIP-1β expression between GCF and PICF levels at week 1 (P=0.02), and within PICF level between 1 and 4 weeks showed statistical significance (P=0.03) within site A. Conclusion: It is possible to detect differential response to surgical trauma at two simultaneously created wound sites within an oral cavity. IL-8, IL-1β, MIP-1β, IL-6 and TNF-α are promising markers to monitor wound healing response in peri-implant tissues. Statistically significant correlations were noted between IP-10 and PICF (P=0.02; r=0.505) and between IL-1β and PICF (P=0.04; r=0.458) after one week of healing. A significant correlation between TNF-α and PD was noted at week 4 (P=0.026; r=0.405)</p><p>(This study is supported through a grant from Straumann USA, KCA-64).</p> 2012-06-27 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1338117117 http://rave.ohiolink.edu/etdc/view?acc_num=osu1338117117 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Dentistry peri-implant wound healing cytokines crevicular fluid RFA
spellingShingle	Dentistry peri-implant wound healing cytokines crevicular fluid RFA Lee, Connie SITE-SPECIFIC CHARACTERISTICS OF PERI-IMPLANT WOUND
author	Lee, Connie
author_facet	Lee, Connie
author_sort	Lee, Connie
title	SITE-SPECIFIC CHARACTERISTICS OF PERI-IMPLANT WOUND
title_short	SITE-SPECIFIC CHARACTERISTICS OF PERI-IMPLANT WOUND
title_full	SITE-SPECIFIC CHARACTERISTICS OF PERI-IMPLANT WOUND
title_fullStr	SITE-SPECIFIC CHARACTERISTICS OF PERI-IMPLANT WOUND
title_full_unstemmed	SITE-SPECIFIC CHARACTERISTICS OF PERI-IMPLANT WOUND
title_sort	site-specific characteristics of peri-implant wound
publisher	The Ohio State University / OhioLINK
publishDate	2012
url	http://rave.ohiolink.edu/etdc/view?acc_num=osu1338117117
work_keys_str_mv	AT leeconnie sitespecificcharacteristicsofperiimplantwound
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SITE-SPECIFIC CHARACTERISTICS OF PERI-IMPLANT WOUND

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