Graphic Network based Methods in Discovering TFBS Motifs

Graphic Network based Methods in Discovering TFBS Motifs

Bibliographic Details
Main Author: Li, Lizhi
Language:English
Published: The Ohio State University / OhioLINK 2012
Subjects:
Biophysics
Motif
discovery
graph
graphic
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1325276730
id ndltd-OhioLink-oai-etd.ohiolink.edu-osu1325276730
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu13252767302021-08-03T06:04:33Z Graphic Network based Methods in Discovering TFBS Motifs Li, Lizhi Biophysics Motif discovery graph graphic To find motifs of transcriptional factors binding sites (TFBS) is essential to understand many biological processes in a cell. Currently the algorithms in discovering the motifs can be divided into three categories: word numeration methods, probabilistic based methods and newly developed graphic network based methods. Graphic network based methods show their advantages over the other two categories of algorithms on prediction accuracy, sensitivity and specificity.This thesis gives a comprehensive overview the main motif discovery methods which are being used now and especially, focuses on the introduction of graphic network based methods. In addition, a study in discovering the TFBS motifs of E2F1, which is a well-known transcription factor, is performed by applying graphic network based algorithms. 2012-01-06 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1325276730 http://rave.ohiolink.edu/etdc/view?acc_num=osu1325276730 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biophysics
Motif
discovery
graph
graphic
spellingShingle Biophysics
Motif
discovery
graph
graphic
Li, Lizhi
Graphic Network based Methods in Discovering TFBS Motifs
author Li, Lizhi
author_facet Li, Lizhi
author_sort Li, Lizhi
title Graphic Network based Methods in Discovering TFBS Motifs
title_short Graphic Network based Methods in Discovering TFBS Motifs
title_full Graphic Network based Methods in Discovering TFBS Motifs
title_fullStr Graphic Network based Methods in Discovering TFBS Motifs
title_full_unstemmed Graphic Network based Methods in Discovering TFBS Motifs
title_sort graphic network based methods in discovering tfbs motifs
publisher The Ohio State University / OhioLINK
publishDate 2012
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1325276730
work_keys_str_mv AT lilizhi graphicnetworkbasedmethodsindiscoveringtfbsmotifs
_version_ 1719430416731996160

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