Influence of Exercise on the Distribution of <sup>99m</sup>Technetium-Methylene Diphosphonate Following Intra-articular Injection in Horses
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The Ohio State University / OhioLINK
2011
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ndltd-OhioLink-oai-etd.ohiolink.edu-osu13061599152021-08-03T06:02:41Z Influence of Exercise on the Distribution of <sup>99m</sup>Technetium-Methylene Diphosphonate Following Intra-articular Injection in Horses Dulin, Jennifer Anne Animal Diseases Pharmacology Radiology Sports Medicine Veterinary Services pharmacokinetics exercise physiology horse technetium <p>Objective: To determine the effects of exercise on the distribution and pharmacokinetic parameters of <sup>99m</sup>technetium-methylene diphosphonate (<sup>99m</sup>Tc-MDP) following intra-articular (IA) injection in horses.</p><p>Animals: 5 horses.</p><p>Procedures: In this randomized, controlled, crossover study, one antebrachiocarpal joint (ACJ) per horse was assigned to the Exercised group (n=5), and the contralateral ACJ was evaluated in the Non-Exercised group (n=5) after a minimum of 7 days. Following IA injection of <sup>99m</sup>Tc-MDP (148 MBq), blood and scintigraphic images of the carpus were obtained at 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 240, 360, 480, 600, 720, and 1440 minutes. Plasma and scintigraphic radioactivity were determined over time, and pharmacokinetic parameters were generated via non-compartmental and compartmental analyses. Each horse was monitored by physical and lameness examination and ACJ synovial fluid analysis before injection and at days 1, 2, 3, and 7.</p><p>Results: Lameness was not observed. Mean synovial fluid WBC count increased at day 1 (Exercised: 721 ± 234 cells/uL, p < 0.05; Non-Exercised: 948 ± 223 cells/uL, p < 0.01), but returned to baseline at days 3 and 7. Mean time to maximum plasma radioactivity was earlier in the Exercised group (16.00 ± 2.35 min) than the Non-Exercised group (43.75 ± 3.64 min) (p < 0.001). Linear regression of the scintigraphic radioactivity-time curves showed a greater negative slope in the Exercised group within the first 25 minutes (p = 0.03). There was no difference in absorption or elimination rate constants in a 2-compartment model.</p><p>Conclusions and Clinical Relevance: Intra-articular <sup>99m</sup>Tc-MDP was safe and effective for evaluating synovial solute distribution. Exercise significantly increased early transfer of <sup>99m</sup>Tc-MDP from the ACJ into plasma, although absorption and elimination rate constants were not affected. Exercise may affect synovial clearance and withdrawal times of IA medications.</p> 2011-07-22 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1306159915 http://rave.ohiolink.edu/etdc/view?acc_num=osu1306159915 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Animal Diseases Pharmacology Radiology Sports Medicine Veterinary Services pharmacokinetics exercise physiology horse technetium |
| spellingShingle |
Animal Diseases Pharmacology Radiology Sports Medicine Veterinary Services pharmacokinetics exercise physiology horse technetium Dulin, Jennifer Anne Influence of Exercise on the Distribution of <sup>99m</sup>Technetium-Methylene Diphosphonate Following Intra-articular Injection in Horses |
| author |
Dulin, Jennifer Anne |
| author_facet |
Dulin, Jennifer Anne |
| author_sort |
Dulin, Jennifer Anne |
| title |
Influence of Exercise on the Distribution of <sup>99m</sup>Technetium-Methylene Diphosphonate Following Intra-articular Injection in Horses |
| title_short |
Influence of Exercise on the Distribution of <sup>99m</sup>Technetium-Methylene Diphosphonate Following Intra-articular Injection in Horses |
| title_full |
Influence of Exercise on the Distribution of <sup>99m</sup>Technetium-Methylene Diphosphonate Following Intra-articular Injection in Horses |
| title_fullStr |
Influence of Exercise on the Distribution of <sup>99m</sup>Technetium-Methylene Diphosphonate Following Intra-articular Injection in Horses |
| title_full_unstemmed |
Influence of Exercise on the Distribution of <sup>99m</sup>Technetium-Methylene Diphosphonate Following Intra-articular Injection in Horses |
| title_sort |
influence of exercise on the distribution of <sup>99m</sup>technetium-methylene diphosphonate following intra-articular injection in horses |
| publisher |
The Ohio State University / OhioLINK |
| publishDate |
2011 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1306159915 |
| work_keys_str_mv |
AT dulinjenniferanne influenceofexerciseonthedistributionofsup99msuptechnetiummethylenediphosphonatefollowingintraarticularinjectioninhorses |
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1719429959594803200 |