Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes

Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes

Bibliographic Details
Main Author: Panyasing, Yaowalak
Language:English
Published: The Ohio State University / OhioLINK 2010
Subjects:
Biomedical Research
hypertrophy
rabbits
torsades de pointes
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1279381163
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu12793811632021-08-03T06:00:16Z Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes Panyasing, Yaowalak Biomedical Research hypertrophy rabbits torsades de pointes Cardiac hypertrophy is an independent risk factor for torsades de pointes (TdP), a polymorphic ventricular tachycardia that is often drug-induced, but that may terminate spontaneously or evolve into ventricular fibrillation and sudden death. People with ventricular hypertrophy or heart failure have an increased risk of drug-induced arrhythmias, therefore this study was designed to determine if right (RVH), left (LVH), or biventricular (BVH) hypertrophy increases susceptibility to drug-induced TdP. Rabbits were separated into 4 groups: control or RVH, LVH, BVH (studied 8 weeks after banding of one or both great arteries). ECGs were recorded continuously after baseline and after rabbits received escalating doses of torsadogens (dofetilide, clofilium and terfenadine) or non-torsadogens (cilobradine, diltiazem and vehicle). The following parameters were measured [RR, PQ, QRS, and QT] or calculated [QTc (F), short term variability of QT interval]. Generally, torsadogenicity for the compounds tested was dofetilide > clofilium > terfenadine, and there was no TdP following cilobradine, diltiazem or vehicle. In general the susceptibility to TdP was RVH > BVH > LVH > control. Rabbits with RVH developed TdP much more prevalently than for those with either LVH or BVH (p < 0.05). At low doses of dofetilide, LVH was actually protective. Rabbits with any form of hypertrophy develop prolongation of QT, QTc and increased QT instability. Rabbits with any form of hypertrophy are more prone to arrhythmia than normals in response to known torsadogens. 2010-09-27 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1279381163 http://rave.ohiolink.edu/etdc/view?acc_num=osu1279381163 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biomedical Research
hypertrophy
rabbits
torsades de pointes
spellingShingle Biomedical Research
hypertrophy
rabbits
torsades de pointes
Panyasing, Yaowalak
Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes
author Panyasing, Yaowalak
author_facet Panyasing, Yaowalak
author_sort Panyasing, Yaowalak
title Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes
title_short Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes
title_full Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes
title_fullStr Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes
title_full_unstemmed Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes
title_sort uni- or bi- ventricular hypertrophy and susceptibility to drug- induced torsades de pointes
publisher The Ohio State University / OhioLINK
publishDate 2010
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1279381163
work_keys_str_mv AT panyasingyaowalak uniorbiventricularhypertrophyandsusceptibilitytodruginducedtorsadesdepointes
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