The Arabidopsis nucleoporin NUA is involved in mRNA export and functionally interacts with spindle assembly checkpoint proteins

Bibliographic Details
Main Author:	Muthuswamy, Sivaramakrishnan
Language:	English
Published:	The Ohio State University / OhioLINK 2009
Subjects:	Cellular Biology Nuclear pore nucleoporin NPC spindle assembly check point SAC AtMAD1 NUA AtMAD2 mRNA export heat stress ethanol stress SUMO sumoylation
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=osu1262122134

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-osu12621221342021-08-03T05:58:05Z The Arabidopsis nucleoporin NUA is involved in mRNA export and functionally interacts with spindle assembly checkpoint proteins Muthuswamy, Sivaramakrishnan Cellular Biology Nuclear pore nucleoporin NPC spindle assembly check point SAC AtMAD1 NUA AtMAD2 mRNA export heat stress ethanol stress SUMO sumoylation The nuclear pore complex (NPC) is essential for macromolecular trafficking and facilitates the exchange of information between the nucleus and the cytoplasm in the eukaryotic cells. The fungal and mammalian NPCs have been well studied through a variety of methods, including isolation of NPCs and identification of the component proteins. In plants, both the protein components of and various molecular activities associated with the NPC are poorly understood. Recent studies have implicated the plant NPC in several cellular processes, including plant-microbe interactions, hormone signaling, mRNA export and stress tolerance. This highlights the necessity to thoroughly understand NPC-associated molecular activities in plants. In other systems, proteins found in the NPC also have functions during mitosis, specifically in spindle assembly. Spindle assembly checkpoint (SAC) proteins are crucial for proper cell division across the eukaryotes. I have characterized Arabidopsis nucleoporin, NUA, and have identified and characterized an Arabidopsis SAC protein, AtMAD1. My work suggests that NUA has functions during mitosis and that it interacts with AtMAD1. 2009 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1262122134 http://rave.ohiolink.edu/etdc/view?acc_num=osu1262122134 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Cellular Biology Nuclear pore nucleoporin NPC spindle assembly check point SAC AtMAD1 NUA AtMAD2 mRNA export heat stress ethanol stress SUMO sumoylation
spellingShingle	Cellular Biology Nuclear pore nucleoporin NPC spindle assembly check point SAC AtMAD1 NUA AtMAD2 mRNA export heat stress ethanol stress SUMO sumoylation Muthuswamy, Sivaramakrishnan The Arabidopsis nucleoporin NUA is involved in mRNA export and functionally interacts with spindle assembly checkpoint proteins
author	Muthuswamy, Sivaramakrishnan
author_facet	Muthuswamy, Sivaramakrishnan
author_sort	Muthuswamy, Sivaramakrishnan
title	The Arabidopsis nucleoporin NUA is involved in mRNA export and functionally interacts with spindle assembly checkpoint proteins
title_short	The Arabidopsis nucleoporin NUA is involved in mRNA export and functionally interacts with spindle assembly checkpoint proteins
title_full	The Arabidopsis nucleoporin NUA is involved in mRNA export and functionally interacts with spindle assembly checkpoint proteins
title_fullStr	The Arabidopsis nucleoporin NUA is involved in mRNA export and functionally interacts with spindle assembly checkpoint proteins
title_full_unstemmed	The Arabidopsis nucleoporin NUA is involved in mRNA export and functionally interacts with spindle assembly checkpoint proteins
title_sort	arabidopsis nucleoporin nua is involved in mrna export and functionally interacts with spindle assembly checkpoint proteins
publisher	The Ohio State University / OhioLINK
publishDate	2009
url	http://rave.ohiolink.edu/etdc/view?acc_num=osu1262122134
work_keys_str_mv	AT muthuswamysivaramakrishnan thearabidopsisnucleoporinnuaisinvolvedinmrnaexportandfunctionallyinteractswithspindleassemblycheckpointproteins AT muthuswamysivaramakrishnan arabidopsisnucleoporinnuaisinvolvedinmrnaexportandfunctionallyinteractswithspindleassemblycheckpointproteins
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The Arabidopsis nucleoporin NUA is involved in mRNA export and functionally interacts with spindle assembly checkpoint proteins

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