EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY
| Main Author: | |
|---|---|
| Language: | English |
| Published: |
The Ohio State University / OhioLINK
2009
|
| Subjects: | |
| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=osu1253548237 |
| id |
ndltd-OhioLink-oai-etd.ohiolink.edu-osu1253548237 |
|---|---|
| record_format |
oai_dc |
| spelling |
ndltd-OhioLink-oai-etd.ohiolink.edu-osu12535482372021-08-03T05:57:21Z EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY Boehm, Michael Chemical Engineering microfluidics CNC machining functional coatings bubble viscoelastic micromixing <p>Rheology, simply stated as the study of the flow and deformation of matter, is afield with grand importance yet a meager following. Be it velocity distributions andturbulence within the Sun or the flow of jelly from your donut’s center, the field ofrheology offers tools to understanding the simple to the complex. For example, onesuch simple experiment that hides far more complex dynamics is the flow of a lowviscosity fluid through a much higher viscosity liquid. This is also known as coringflow and has been studied extensively for the macro-scale. The dynamics for coringflow have not been studied, to the best of the author's knowledge, on the micro-scaleand it is that disparity the research detailed here addresses.</p><p>There are many important aspects to consider before performing multiphasemicro-fluidic research including what micro-fabrication methods are used, how themicrochip is interfaced to the macro-world, how the fluids will behave, and how themicro-channel geometry will affect the dynamics. This dissertation addresses thosetopics as they apply to the research performed and detailed here. Three differentfabrication techniques are explained, detailed, and used to highlight the benefits anddrawbacks of working on the micro-scale. Bonding is also an important part offabrication and so two different methods are discussed. Finally, the way a microchip isinterfaced to the macro-world affects the correlations that can be made. Three differentinterfacing systems that worked well are presented.</p><p>The fundamental process of coring on the micro-scale is investigated andexplained for circular, square, and rectangular geometries. The simple case of aNewtonian coating fluid was researched first, followed by the case of a viscoelasticcoating fluid, and finally the case where the coring fluid contained a surfactant. It wasfound that, in general, micro-scale coring matches that of the macro-scale except for thecase of a viscoelastic coating fluid. New bubble behavior was observed for high flowrates through a viscoelastic coating fluid.</p><p>As engineers, we wrestle something practical out of our understanding of thefundamental. This principle was the driving motivation behind the three practicalapplications of micro-scale coring flow that were. Coring flow was used to add afunctional coating to capillaries for use in Capillary Electrophoresis, to coat a staticmixer, and to create nozzle-like structures in a micro-channel. The final goal of thesepractical applications was to develop a toolbox of procedures and data that can be usedin a wide array of fields including (a) coatings to reduce non-specific binding indrug/gene delivery applications, (b) coatings for separation and detection techniqueslike Capillary Electrophoresis, and (c) a simple means to smoothing rough channelsmade via micro-/nano-machining.</p> 2009-10-01 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1253548237 http://rave.ohiolink.edu/etdc/view?acc_num=osu1253548237 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Chemical Engineering microfluidics CNC machining functional coatings bubble viscoelastic micromixing |
| spellingShingle |
Chemical Engineering microfluidics CNC machining functional coatings bubble viscoelastic micromixing Boehm, Michael EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY |
| author |
Boehm, Michael |
| author_facet |
Boehm, Michael |
| author_sort |
Boehm, Michael |
| title |
EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY |
| title_short |
EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY |
| title_full |
EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY |
| title_fullStr |
EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY |
| title_full_unstemmed |
EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY |
| title_sort |
experimental investigation of two-phase penetrating flow of newtonian and non-newtonian polymeric fluids and development of practical applications in drug/gene delivery |
| publisher |
The Ohio State University / OhioLINK |
| publishDate |
2009 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1253548237 |
| work_keys_str_mv |
AT boehmmichael experimentalinvestigationoftwophasepenetratingflowofnewtonianandnonnewtonianpolymericfluidsanddevelopmentofpracticalapplicationsindruggenedelivery |
| _version_ |
1719428366922153984 |