Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development

Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development

Bibliographic Details
Main Author: KEEN, KRISTIN C.
Language:English
Published: The Ohio State University / OhioLINK 2009
Subjects:
Pathology
CHRONIC LYMPHOCYTIC LEUKEMIA
CORRELATION
CRC
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1230840233
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu12308402332021-08-03T05:55:05Z Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development KEEN, KRISTIN C. Pathology CHRONIC LYMPHOCYTIC LEUKEMIA CORRELATION CRC Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the United States. There is no known cure for CLL. While biomarkers have been found to correlate with disease progression, such as CD38, IGHV, and ZAP-70, there is a need for further validation of these biomarkers as well as new biomarker discovery. In this study, publicly available gene expression data from NCBI's Gene Expression Omnibus was used to identify genes with expression correlated to ZAP-70 and CD38 mRNA expression patterns. Also utilized were vast amounts of data from the Chronic Lymphocytic Leukemia Research Consortium (CRC) to search for novel correlations between clinical markers and disease progression and treatment outcome. We found several hundred genes with expression patterns correlated to ZAP-70. We also found several clinical, genetic, biologic, and immunologic CRC data fields which were correlated significantly and at weakly to strongly associated. 2009-02-04 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1230840233 http://rave.ohiolink.edu/etdc/view?acc_num=osu1230840233 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Pathology
CHRONIC LYMPHOCYTIC LEUKEMIA
CORRELATION
CRC
spellingShingle Pathology
CHRONIC LYMPHOCYTIC LEUKEMIA
CORRELATION
CRC
KEEN, KRISTIN C.
Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development
author KEEN, KRISTIN C.
author_facet KEEN, KRISTIN C.
author_sort KEEN, KRISTIN C.
title Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development
title_short Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development
title_full Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development
title_fullStr Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development
title_full_unstemmed Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development
title_sort use of chronic lymphocytic leukemia research consortium data repository and gene expression omnibus to generate and test hypotheses for biomarker identification and development
publisher The Ohio State University / OhioLINK
publishDate 2009
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1230840233
work_keys_str_mv AT keenkristinc useofchroniclymphocyticleukemiaresearchconsortiumdatarepositoryandgeneexpressionomnibustogenerateandtesthypothesesforbiomarkeridentificationanddevelopment
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