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ndltd-OhioLink-oai-etd.ohiolink.edu-osu12185668302021-08-03T05:54:20Z Role of inhibition and hyperpolarization-activated membrane properties in a lick/gape central pattern generator Venugopal, Sharmila The interplay between intrinsic and synaptic properties is an important determinantof the outputs of a central pattern generating network (CPG). The studiespresented in this thesis are focused towards understanding the intrinsic and synaptic mechanisms underlying a brainstem central pattern generator, orchestrating taste-induced ingestion and rejection responses. A combination of computational and mathematical modeling with whole cell electrophysiology are used for these studies. Using mathematical and computational methods, we show that the magnitude and kinetics of inhibitory synaptic currents can be critical for the strength and patterning of the motor outputs of taste-induced licks (ingestion) and gapes (rejection). Using whole cell electrophysiology, we explore the hyperpolarization-activated intrinsic properties of the potential CPG neurons in a brainstem slice preparation. We classify these neurons based on hyperpolarization-induced facilitation or suppression of spikes. Additionally, we show the existence of a hyperpolarization-induced inward cation current (I<sub>h</sub>), a transient A-type potassium current (I<sub>A</sub>) among these neurons.We conclude that the hyperpolarization-induced changes in excitability do not ariseby mere existence or absence of one type of ionic current. Rather, overlapping combinations of currents dynamically interact to lend specific groups of neurons more or less excitable as they recover from hyperpolarization/inhibition. We speculate that the intrinsic firing properties observed in these neurons may play a role during lick-gape pattern generation. In addition to being the first studies to reveal various intrinsic and synaptic mechanisms of lick/gape pattern generation at both single cell and network level, these studies have laid the foundation for several future experimentation and mathematical modeling to understand the workings of the CPG under study. 2008-09-11 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1218566830 http://rave.ohiolink.edu/etdc/view?acc_num=osu1218566830 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
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NDLTD
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| language |
English
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NDLTD
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| author |
Venugopal, Sharmila
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| spellingShingle |
Venugopal, Sharmila
Role of inhibition and hyperpolarization-activated membrane properties in a lick/gape central pattern generator
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Venugopal, Sharmila
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Venugopal, Sharmila
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| title |
Role of inhibition and hyperpolarization-activated membrane properties in a lick/gape central pattern generator
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| title_short |
Role of inhibition and hyperpolarization-activated membrane properties in a lick/gape central pattern generator
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| title_full |
Role of inhibition and hyperpolarization-activated membrane properties in a lick/gape central pattern generator
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| title_fullStr |
Role of inhibition and hyperpolarization-activated membrane properties in a lick/gape central pattern generator
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| title_full_unstemmed |
Role of inhibition and hyperpolarization-activated membrane properties in a lick/gape central pattern generator
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| title_sort |
role of inhibition and hyperpolarization-activated membrane properties in a lick/gape central pattern generator
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| publisher |
The Ohio State University / OhioLINK
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| publishDate |
2008
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| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1218566830
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AT venugopalsharmila roleofinhibitionandhyperpolarizationactivatedmembranepropertiesinalickgapecentralpatterngenerator
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1719427514526334976
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