Data acquisition and reconstruction techniques for improved electron paramagnetic resonance (EPR) imaging

Data acquisition and reconstruction techniques for improved electron paramagnetic resonance (EPR) imaging

Bibliographic Details
Main Author: Ahmad, Rizwan
Language:English
Published: The Ohio State University / OhioLINK 2007
Subjects:
EPR
EPRI
Oximetry
4D Radon Transform
Filtered Backprojection
Fekete
ART
MART
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1186602293
id ndltd-OhioLink-oai-etd.ohiolink.edu-osu1186602293
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu11866022932021-08-03T05:52:35Z Data acquisition and reconstruction techniques for improved electron paramagnetic resonance (EPR) imaging Ahmad, Rizwan EPR EPRI Oximetry 4D Radon Transform Filtered Backprojection Fekete ART MART Electron paramagnetic resonance imaging (EPRI) is capable of measuring both endogenous and introduced free radical distributions in variety of biological systems. Despite the inherent potential, the broad use of EPRI is hampered by slow acquisition which can be the bottleneck for many biological applications where conditions may change over time. The objective of this work is to reduce the data acquisition time without degrading the reconstruction quality. First, we have modeled the data acquisition process for both spatial and spectral-spatial imaging in the form of Radon transform. Efficient-to-program expressions for Radon and inverse Radon transform for 2D, 3D, and 4D EPRI are derived. Second, we have proposed a method to uniformly distribute the data for both 3D and 4D EPRI which, from fewer projections, can generate reconstruction results which are better than those based on the existing nonuniform or partially uniform sampling techniques. The expected savings in the acquisition time offered by the suggested uniform sampling are 30% and 50% for 3D and 4D, respectively. In addition, we have also discussed existing uniform sampling methods and compared their performance with the suggested method using simulation and experimental data. Third, we have suggested a single-stage filtered backprojection reconstruction for 3D and 4D EPRI using the partial Radon transform for 4-fold acceleration. This substantial speed up further motivated us to reconsider the iterative reconstruction methods such as algebraic reconstruction which, despite having the superior performance in terms of reconstruction quality, have not been routinely used for 3D and 4D reconstructions due to their slow speeds. With the use of partial Radon transform, along with proper choice of interpolation type, the 3D iterative reconstruction time is reduced by more than 80%, which implies that a 64×64×64 image can be reconstructed from 150 projections using 100 iterations in approximately 10 minutes with ordinary contemporary computing resources. Further, the ability of the iterative methods to model EPR related constraints and to incorporate any other <i>a priori</i> information, such as nonnegativity, has also been demonstrated. Again, both simulation and experimental data are used to evaluate and compare the suggested reconstruction procedures. 2007-08-23 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1186602293 http://rave.ohiolink.edu/etdc/view?acc_num=osu1186602293 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic EPR
EPRI
Oximetry
4D Radon Transform
Filtered Backprojection
Fekete
ART
MART
spellingShingle EPR
EPRI
Oximetry
4D Radon Transform
Filtered Backprojection
Fekete
ART
MART
Ahmad, Rizwan
Data acquisition and reconstruction techniques for improved electron paramagnetic resonance (EPR) imaging
author Ahmad, Rizwan
author_facet Ahmad, Rizwan
author_sort Ahmad, Rizwan
title Data acquisition and reconstruction techniques for improved electron paramagnetic resonance (EPR) imaging
title_short Data acquisition and reconstruction techniques for improved electron paramagnetic resonance (EPR) imaging
title_full Data acquisition and reconstruction techniques for improved electron paramagnetic resonance (EPR) imaging
title_fullStr Data acquisition and reconstruction techniques for improved electron paramagnetic resonance (EPR) imaging
title_full_unstemmed Data acquisition and reconstruction techniques for improved electron paramagnetic resonance (EPR) imaging
title_sort data acquisition and reconstruction techniques for improved electron paramagnetic resonance (epr) imaging
publisher The Ohio State University / OhioLINK
publishDate 2007
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1186602293
work_keys_str_mv AT ahmadrizwan dataacquisitionandreconstructiontechniquesforimprovedelectronparamagneticresonanceeprimaging
_version_ 1719426953680781312

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