Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control

Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control

Bibliographic Details
Main Author: Wenzel, Pamela L.
Language:English
Published: The Ohio State University / OhioLINK 2007
Subjects:
Rb
E2F
Transcription factors
Development
Placenta
Trophoblast
Stem cells
Lens
Apoptosis
Differentiation
Proliferation
Cell cycle
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1179341665
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu11793416652021-08-03T05:52:04Z Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control Wenzel, Pamela L. Rb E2F Transcription factors Development Placenta Trophoblast Stem cells Lens Apoptosis Differentiation Proliferation Cell cycle The Rb-E2F pathway has been the focus of a tremendous body of research, due in large part to its well-recognized role in tumorigenesis. We report in this study a role for Rb in limiting proliferation of trophoblast stem cells during development of the mouse placenta. These findings point to a critical role for Rb at a time when stem cells are beginning to differentiate. We also address the role of Rb binding partners, E2F1, E2F2, and E2F3, in stem and progenitor cell biology in vivo and in vitro. We find that these transcriptional activators are largely dispensable for proliferation in pluripotent stem cells and in many differentiated cell types; however, E2F1-3 do appear to be critical for cell cycle regulation and survival during and after differentiation of specific lineages. Further, we explore the implications of our findings for the current paradigm of E2F function and consider novel roles for E2F that may be largely independent of transcriptional control of cell cycle-regulated gene expression. Appreciating how these genes function in stem cells will be key to understanding how they impact the cell cycle, senescence, self-renewal, proliferation, apoptosis, and differentiation programs during normal development and tumorigenesis. 2007-07-10 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1179341665 http://rave.ohiolink.edu/etdc/view?acc_num=osu1179341665 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Rb
E2F
Transcription factors
Development
Placenta
Trophoblast
Stem cells
Lens
Apoptosis
Differentiation
Proliferation
Cell cycle
spellingShingle Rb
E2F
Transcription factors
Development
Placenta
Trophoblast
Stem cells
Lens
Apoptosis
Differentiation
Proliferation
Cell cycle
Wenzel, Pamela L.
Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control
author Wenzel, Pamela L.
author_facet Wenzel, Pamela L.
author_sort Wenzel, Pamela L.
title Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control
title_short Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control
title_full Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control
title_fullStr Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control
title_full_unstemmed Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control
title_sort role of the rb-e2f pathway in embryonic development: implications for paradigms of cell cycle control
publisher The Ohio State University / OhioLINK
publishDate 2007
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1179341665
work_keys_str_mv AT wenzelpamelal roleoftherbe2fpathwayinembryonicdevelopmentimplicationsforparadigmsofcellcyclecontrol
_version_ 1719426839494000640

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