A role for cytoplasmic PML in the cellular antiviral response

A role for cytoplasmic PML in the cellular antiviral response

Bibliographic Details
Main Author: McNally, Beth Anne
Language:English
Published: The Ohio State University / OhioLINK 2005
Subjects:
cytoplasmic PML
HSV-1
ICP0
RNA editing
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1133377007
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu11333770072021-08-03T05:50:32Z A role for cytoplasmic PML in the cellular antiviral response McNally, Beth Anne cytoplasmic PML HSV-1 ICP0 RNA editing In the co-evolution of cellular host and virus, both cellular and viral proteins and their protein functions have adapted to equip each player for a battle of survival. In pages to follow we characterize a novel cellular antiviral molecule called PML Ib, and shed some light on the delicate interplay that exists between this cellular protein and the HSV-1 Immediate Early Infected Cell Protein 0 (ICP0). Herein our studies reveal a surprising role for a unique cytoplasmic isoform of PML in the cellular defense of HSV-1. Our data supports a model by which PML Ib influences the proteosomal degradation of ICP0 and renders wild type infections similar to that of ICP0 null mutants, We also show that the 3’ untranslated (UTR) region of PML Ib is subject to nucleotidic editing implicating a means by which this particular PML isoform may be regulated and manipulated. Lastly, we uncover a mechanism by which a virus other than HSV-1 may evade the antiviral shield set up by PML Ib implicating, perhaps, a more expansive role for this protein as an induced effector molecule of the innate immune response. 2005-12-02 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1133377007 http://rave.ohiolink.edu/etdc/view?acc_num=osu1133377007 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic cytoplasmic PML
HSV-1
ICP0
RNA editing
spellingShingle cytoplasmic PML
HSV-1
ICP0
RNA editing
McNally, Beth Anne
A role for cytoplasmic PML in the cellular antiviral response
author McNally, Beth Anne
author_facet McNally, Beth Anne
author_sort McNally, Beth Anne
title A role for cytoplasmic PML in the cellular antiviral response
title_short A role for cytoplasmic PML in the cellular antiviral response
title_full A role for cytoplasmic PML in the cellular antiviral response
title_fullStr A role for cytoplasmic PML in the cellular antiviral response
title_full_unstemmed A role for cytoplasmic PML in the cellular antiviral response
title_sort role for cytoplasmic pml in the cellular antiviral response
publisher The Ohio State University / OhioLINK
publishDate 2005
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1133377007
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AT mcnallybethanne roleforcytoplasmicpmlinthecellularantiviralresponse
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