The Acute-Phase Response and Cancer Risk
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2003
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=osu1053636439 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-osu10536364392021-08-03T05:47:51Z The Acute-Phase Response and Cancer Risk Sivak-Sears, Niccole R. Acute-Phase Response Inflammatory Response Cancer Risk Lung Cancer Serum Antioxidants Serum Ferritin Periodontal Disease NSAIDs Glioblastoma Multiforme This dissertation contains three investigations that evaluate hypotheses concerning associations between the acute phase response (APR) and cancer. The APR is a coordinated sequence of systemic and metabolic changes occurring in response to acute and chronic stimuli, including pathogens, injury, and cancer. The goal of the first investigation (chapter 2) was to determine whether the previously observed associations between serum antioxidant and ferritin concentrations and cancer risk are actually attributable to the effect of the APR (caused by the pre-existing cancer) on serum antioxidant and ferritin levels. Individuals with 1) a prior cancer diagnosis, 2) previous heart attack, and 3) neither a history of cancer nor heart attack, had similar serum antioxidant levels so the question of whether the APR is responsible for the decrease of serum antioxidants observed in cancer patients could not be addressed. However, individuals in the cancer and heart attack groups with the highest APRs showed higher serum ferritin levels and lower serum iron levels than did individuals with the highest APRs in the group without these diseases. These findings suggest that the APR is responsible for differences in serum ferritin and serum iron levels among the three groups. The second investigation (chapter 3) evaluated the association between the chronic inflammatory condition, periodontal disease, and risk of lung cancer. We found no association between periodontal disease and lung cancer risk in women. Among men, a statistically significant trend of an increase in lung cancer risk with increasing periodontal disease severity was observed (p=0.0008), however this risk was restricted to smoking males; nonsmoking males showed no association between periodontal disease and lung cancer risk. These findings indicate either a modifying effect of smoking on gum disease or residual confounding by smoking. The third investigation (chapter 4) evaluated the association between use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) and adult glioblastoma multiforme risk. Self-reported glioblastoma multiforme cases were less likely than controls to report use of at least 600 pills of all types of NSAIDs combined during the ten year pre-diagnostic period. Findings were consistent for aspirin, ibuprofen, and naproxen/other NSAIDs, as well as for acetaminophen. 2003-08-06 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1053636439 http://rave.ohiolink.edu/etdc/view?acc_num=osu1053636439 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Acute-Phase Response Inflammatory Response Cancer Risk Lung Cancer Serum Antioxidants Serum Ferritin Periodontal Disease NSAIDs Glioblastoma Multiforme |
| spellingShingle |
Acute-Phase Response Inflammatory Response Cancer Risk Lung Cancer Serum Antioxidants Serum Ferritin Periodontal Disease NSAIDs Glioblastoma Multiforme Sivak-Sears, Niccole R. The Acute-Phase Response and Cancer Risk |
| author |
Sivak-Sears, Niccole R. |
| author_facet |
Sivak-Sears, Niccole R. |
| author_sort |
Sivak-Sears, Niccole R. |
| title |
The Acute-Phase Response and Cancer Risk |
| title_short |
The Acute-Phase Response and Cancer Risk |
| title_full |
The Acute-Phase Response and Cancer Risk |
| title_fullStr |
The Acute-Phase Response and Cancer Risk |
| title_full_unstemmed |
The Acute-Phase Response and Cancer Risk |
| title_sort |
acute-phase response and cancer risk |
| publisher |
The Ohio State University / OhioLINK |
| publishDate |
2003 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1053636439 |
| work_keys_str_mv |
AT sivaksearsniccoler theacutephaseresponseandcancerrisk AT sivaksearsniccoler acutephaseresponseandcancerrisk |
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1719425441148698624 |