MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE

MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE

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Bibliographic Details
Main Author: Mattern, Craig O.
Language:English
Published: The Ohio State University / OhioLINK 2002
Subjects:
lactate
aging
metabolism
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1039034888
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu10390348882021-08-03T05:47:51Z MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE Mattern, Craig O. lactate aging metabolism Increased participation of aged individuals in competitive athletics warrants basic research focused on delineating age-related changes in performance variables. PURPOSE: Based on potential age-related declines in aerobic enzyme activities and a shift in the expression of myosin heavy chain (MHC) isoforms, we hypothesized that maximal lactate steady state (MLSS) exercise intensity would be altered as a function of age. METHODS: Three age groups [(YA, n=10, 25.1±0.9 years, 8.3±1.0 % fat) (MA, n=10, 42.9±1.0 years, 13.6±1.9 % fat) (OA, n=10, 63.9±2.5 years, 16.4±1.4 % fat)] of male, competitive cyclists and triathletes matched for training intensity and duration were studied. Subjects performed a VO2max test followed by a series of 30 min exercise trials to determine MLSS. The intensity of the first trial was 60% of maximal power output measured during the VO2max test. Workload of each subsequent trial was increased by 5% until blood lactate increased by > 1 mMol/L in the last 20 min of the 30 min trial. A muscle biopsy of the vastus lateralis was procured on a separate visit. RESULTS: There were significant (p<0.05) differences in VO2max between all age groups (YA = 66.9±1.4 ml•kg-1•min-1, MA = 55.5±2.4 ml•kg-1•min-1, OA = 46.8±2.3 ml•kg-1•min-1). When expressed as a percentage of VO2max, there was also a significant (p<0.05) age-related decrease in the relative MLSS exercise intensity (YA = 82.2±1.7%, MA = 76.0±1.3%, OA = 70.1±1.4%). However, there were no significant age-related changes in citrate synthase (CS) activity or MHC isoform profile. CONCLUSION: The hypothesis is supported as there is an age-related decline in MLSS exercise intensity in athletes matched for training intensity and duration. Additionally, the rate of this decline is approximately 3.8% per decade. While CS activity is moderately related (r = 0.44, p = 0.008) to relative MLSS intensity, it does not explain the age-related decline in MLSS. The mechanism(s) responsible for the observed age-related decline in MLSS is unknown. Supported by The Gatorade Sports Science Institute. 2002-12-20 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1039034888 http://rave.ohiolink.edu/etdc/view?acc_num=osu1039034888 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic lactate
aging
metabolism
spellingShingle lactate
aging
metabolism
Mattern, Craig O.
MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE
author Mattern, Craig O.
author_facet Mattern, Craig O.
author_sort Mattern, Craig O.
title MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE
title_short MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE
title_full MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE
title_fullStr MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE
title_full_unstemmed MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE
title_sort maximal lactate steady state: influence of the age-related adaptations of skeletal muscle
publisher The Ohio State University / OhioLINK
publishDate 2002
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1039034888
work_keys_str_mv AT matterncraigo maximallactatesteadystateinfluenceoftheagerelatedadaptationsofskeletalmuscle
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