Diet-Induced Obesity in Growth Hormone Receptor Antagonist Mice

Diet-Induced Obesity in Growth Hormone Receptor Antagonist Mice

Bibliographic Details
Main Author: Yang, Tianxu
Language:English
Published: Ohio University / OhioLINK 2010
Subjects:
Biology
Health
Nutrition
GHA
Obesity
Euglycemia
Diet
Body Composition
Adiposity,
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1288987144
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ohiou12889871442021-08-03T05:46:45Z Diet-Induced Obesity in Growth Hormone Receptor Antagonist Mice Yang, Tianxu Biology Health Nutrition GHA Obesity Euglycemia Diet Body Composition Adiposity, Growth hormone receptor antagonist (GHA) mice, with partial repression of GH signaling, have not been challenged with high fat (HF) feeding; therefore, both genders of GHA mice and wild type (WT) controls were fed a HF and a low fat (LF) diet to investigate the susceptibility to diet-induced obesity as well as examine gender differences. Body composition, body weight, and energy intake were measured weekly from 10-21 weeks of age. HF feeding increased body weight, fat mass and percent fat mass for all mice as compared to LF feeding. The body weight gain was due solely to increases in adiposity. Both female GHA and female WT mice exhibited a striking ability to resist fat mass gain as compared to males. Euglycemia was observed in GHA mice when exposed to a HF diet. GHA mice stored more fat mass especially in the subcutaneous pad even though most other organ weights decreased in GHA mice. Overall, GHA male mice were hyperphagic and more sensitive to diet-induced obesity than WT littermates. 2010 English text Ohio University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1288987144 http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1288987144 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biology
Health
Nutrition
GHA
Obesity
Euglycemia
Diet
Body Composition
Adiposity,
spellingShingle Biology
Health
Nutrition
GHA
Obesity
Euglycemia
Diet
Body Composition
Adiposity,
Yang, Tianxu
Diet-Induced Obesity in Growth Hormone Receptor Antagonist Mice
author Yang, Tianxu
author_facet Yang, Tianxu
author_sort Yang, Tianxu
title Diet-Induced Obesity in Growth Hormone Receptor Antagonist Mice
title_short Diet-Induced Obesity in Growth Hormone Receptor Antagonist Mice
title_full Diet-Induced Obesity in Growth Hormone Receptor Antagonist Mice
title_fullStr Diet-Induced Obesity in Growth Hormone Receptor Antagonist Mice
title_full_unstemmed Diet-Induced Obesity in Growth Hormone Receptor Antagonist Mice
title_sort diet-induced obesity in growth hormone receptor antagonist mice
publisher Ohio University / OhioLINK
publishDate 2010
url http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1288987144
work_keys_str_mv AT yangtianxu dietinducedobesityingrowthhormonereceptorantagonistmice
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