Role of nociceptin/orphanin FQ in the prolactin, hypothalamic-pituitary-adrenal axis, and prolactin receptor response to acute stress in rats

Role of nociceptin/orphanin FQ in the prolactin, hypothalamic-pituitary-adrenal axis, and prolactin receptor response to acute stress in rats

Bibliographic Details
Main Author: Hurst, Thomas Eugene
Language:English
Published: Miami University Honors Theses / OhioLINK 2011
Subjects:
Endocrinology
Neurosciences
Physiology
Zoology
N/OFQ
prolactin
HPA axis
prolactin receptor
acute stress
estrogen
rat
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1303421079
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-muhonors13034210792021-08-03T05:42:16Z Role of nociceptin/orphanin FQ in the prolactin, hypothalamic-pituitary-adrenal axis, and prolactin receptor response to acute stress in rats Hurst, Thomas Eugene Endocrinology Neurosciences Physiology Zoology N/OFQ prolactin HPA axis prolactin receptor acute stress estrogen rat Despite the prevalence of anxiety related disorders and postpartum depression, the role of prolactin (PRL) and the endogenous opioid peptide (EOP) nociceptin/orphanin FQ (N/OFQ) on the hypothalamic-pituitary-adrenal (HPA) axis activation in response to acute stress is not known. Animals were pretreated with Compound B (Comp B), a known nociceptin/orphanin peptide (NOP) receptor antagonist, to elucidate the physiological role of N/OFQ in the stress-induced PRL increase, both in the presence and absence of estrogen. Furthermore, N/OFQ’s impact on prolactin receptor (PRL-R) expression upregulation, and thus the amount of PRL uptake into the choroid plexus of the brain following stress was substantial in females. Regardless of exposure to acute stress, estrogen significantly increased PRL-R expression in the choroid plexus. However, the influence of N/OFQ on the HPA axis appeared to be minimal. Following three surgeries (ICV, OVX, IV), despite what was believed to be ample recovery time, animals had elevated plasma corticosteroid levels even prior to the onset of acute stress. Future work will focus on identifying and controlling experimental conditions that, unintentionally, seem to affect HPA axis activity at rest and in response to stress. 2011-05-02 English text Miami University Honors Theses / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1303421079 http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1303421079 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Endocrinology
Neurosciences
Physiology
Zoology
N/OFQ
prolactin
HPA axis
prolactin receptor
acute stress
estrogen
rat
spellingShingle Endocrinology
Neurosciences
Physiology
Zoology
N/OFQ
prolactin
HPA axis
prolactin receptor
acute stress
estrogen
rat
Hurst, Thomas Eugene
Role of nociceptin/orphanin FQ in the prolactin, hypothalamic-pituitary-adrenal axis, and prolactin receptor response to acute stress in rats
author Hurst, Thomas Eugene
author_facet Hurst, Thomas Eugene
author_sort Hurst, Thomas Eugene
title Role of nociceptin/orphanin FQ in the prolactin, hypothalamic-pituitary-adrenal axis, and prolactin receptor response to acute stress in rats
title_short Role of nociceptin/orphanin FQ in the prolactin, hypothalamic-pituitary-adrenal axis, and prolactin receptor response to acute stress in rats
title_full Role of nociceptin/orphanin FQ in the prolactin, hypothalamic-pituitary-adrenal axis, and prolactin receptor response to acute stress in rats
title_fullStr Role of nociceptin/orphanin FQ in the prolactin, hypothalamic-pituitary-adrenal axis, and prolactin receptor response to acute stress in rats
title_full_unstemmed Role of nociceptin/orphanin FQ in the prolactin, hypothalamic-pituitary-adrenal axis, and prolactin receptor response to acute stress in rats
title_sort role of nociceptin/orphanin fq in the prolactin, hypothalamic-pituitary-adrenal axis, and prolactin receptor response to acute stress in rats
publisher Miami University Honors Theses / OhioLINK
publishDate 2011
url http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1303421079
work_keys_str_mv AT hurstthomaseugene roleofnociceptinorphaninfqintheprolactinhypothalamicpituitaryadrenalaxisandprolactinreceptorresponsetoacutestressinrats
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