DORSAL RAPHE PROJECTIONS TO THE MESOCORTICOLIMBIC SYSTEM MODULATE CORE ASPECTS OF APPETITIVE LEARNING AND RESPONDING
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Miami University / OhioLINK
2021
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=miami1625142754853894 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-miami16251427548538942021-08-03T07:17:44Z DORSAL RAPHE PROJECTIONS TO THE MESOCORTICOLIMBIC SYSTEM MODULATE CORE ASPECTS OF APPETITIVE LEARNING AND RESPONDING Tapp, Danielle N. Behavioral Sciences Behavioral Psychology Neurobiology Neurosciences Learning Motivation Animal Behavior Learning about reward predictive cues is an essential component of motivated behaviors in everyday life. This process is disrupted in psychological diseases such as depression and substance use. Identifying the neural circuits that control this process is key to developing treatments for these diseases. The mesocorticolimbic dopamine system plays a strong role in cue learning and responding, however, other brain regions interact with the dopamine system to drive differences in behavior. The dorsal raphe (DRN) has recently been found to interact with the mesocorticolimbic system at the cell bodies in the ventral tegmental area (VTA) and primary projection site nucleus accumbens (NAc). The goal of this project was to establish how excitation of DRN projections to the VTA and DRN projections to the NAc influence learning about reward predictive cues and responding for rewards. We first determined that excitation of DRN to VTA projections enhanced contextual cue learning for drug rewards compared to control subjects. Excitation of DRN to VTA projections is alone reinforcing. DRN to NAc projections enhanced contextual learning for drug rewards. However, DRN to NAc projection excitation alone was found to be aversive. These effects were not explained by an enhanced capacity to learn about contextual information in either group. We next determined how these circuits influenced drug-induced suppression of reward sensitivity. DRN to VTA projection activation did not alter amphetamine’s ability to suppress reward sensitivity, but did not enhance it. DRN to VTA projection excitation alone did not appear to suppress reward sensitivity. Surprisingly, assessment of reward sensitivity in the DRN to NAc condition was not possible as circuit activation ablated operant responding. This data suggested that DRN to NAc projections may uniquely influence the ability of animals to respond for rewards. In our last series of experiments, we tested the influence of DRN projections on instrumental responding, cue learning and pavlovian to instrumental transfer for food rewards. DRN to NAc projections did not influence cue learning, or operant responding but did alter pavlovian to instrumental transfer. Finally, DRN to NAc excitation reduced motivation to obtain food rewards. These data suggest that DRN to VTA projections may enhance contextual learning for drug rewards and produce reinforcing properties. DRN to NAc projections may modulate motivation to obtain rewards and increase the ability of reward selective cues to influence operant responses. This project provides the basis for future investigations of DRN circuitry on drug seeking and motivated behaviors. 2021-07-07 English text Miami University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=miami1625142754853894 http://rave.ohiolink.edu/etdc/view?acc_num=miami1625142754853894 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Behavioral Sciences Behavioral Psychology Neurobiology Neurosciences Learning Motivation Animal Behavior |
| spellingShingle |
Behavioral Sciences Behavioral Psychology Neurobiology Neurosciences Learning Motivation Animal Behavior Tapp, Danielle N. DORSAL RAPHE PROJECTIONS TO THE MESOCORTICOLIMBIC SYSTEM MODULATE CORE ASPECTS OF APPETITIVE LEARNING AND RESPONDING |
| author |
Tapp, Danielle N. |
| author_facet |
Tapp, Danielle N. |
| author_sort |
Tapp, Danielle N. |
| title |
DORSAL RAPHE PROJECTIONS TO THE MESOCORTICOLIMBIC SYSTEM MODULATE CORE ASPECTS OF APPETITIVE LEARNING AND RESPONDING |
| title_short |
DORSAL RAPHE PROJECTIONS TO THE MESOCORTICOLIMBIC SYSTEM MODULATE CORE ASPECTS OF APPETITIVE LEARNING AND RESPONDING |
| title_full |
DORSAL RAPHE PROJECTIONS TO THE MESOCORTICOLIMBIC SYSTEM MODULATE CORE ASPECTS OF APPETITIVE LEARNING AND RESPONDING |
| title_fullStr |
DORSAL RAPHE PROJECTIONS TO THE MESOCORTICOLIMBIC SYSTEM MODULATE CORE ASPECTS OF APPETITIVE LEARNING AND RESPONDING |
| title_full_unstemmed |
DORSAL RAPHE PROJECTIONS TO THE MESOCORTICOLIMBIC SYSTEM MODULATE CORE ASPECTS OF APPETITIVE LEARNING AND RESPONDING |
| title_sort |
dorsal raphe projections to the mesocorticolimbic system modulate core aspects of appetitive learning and responding |
| publisher |
Miami University / OhioLINK |
| publishDate |
2021 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=miami1625142754853894 |
| work_keys_str_mv |
AT tappdaniellen dorsalrapheprojectionstothemesocorticolimbicsystemmodulatecoreaspectsofappetitivelearningandresponding |
| _version_ |
1719458523359739904 |