Interaction of <i>Acinetobacter baumannii</i> with abiotic and biotic environments
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Miami University / OhioLINK
2016
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=miami147937747636766 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-miami1479377476367662021-08-03T06:38:56Z Interaction of <i>Acinetobacter baumannii</i> with abiotic and biotic environments Ohneck, Emily Jean Molecular Biology Genetics Acinetobacter baumannii biofilms motility two-component regulatory systems host-pathogen interactions mucin <i>Acinetobacter baumannii</i> is an opportunistic nosocomial pathogen that has a global impact on human health. The capacity of <i>A. baumannii</i> to cause a wide variety of severe infections, combined with the emergence of multi-drug resistant isolates, present significant challenges toward the development of new therapies to treat <i>A. baumannii</i> infections. Biofilm formation on abiotic surfaces, which is a key factor in the persistence of this pathogen, is controlled by the BfmRS two-component regulatory system (TCS). However, the role of this TCS in other <i>Acinetobacter</i> isolates is not understood. The work presented herein demonstrates that the BfmR response regulator provides conserved global regulatory functions, which includes the regulation of adherence and pathogenicity factors, in both <i>A. baumannii</i> and <i>Acinetobacter nosocomialis</i>. In contrast to the interaction of <i>A. baumannii</i> with abiotic surfaces, the mechanism by which this pathogen regulates attachment and virulence factors in biotic environments is unknown. Our work provides insight into this pathway by demonstrating that <i>A. baumannii</i> responds to mucin, a major component secreted by lung epithelial cells particularly during respiratory infections, which triggers a cascade of responses that allow this pathogen to acquire critical nutrients and enhance the expression of virulence factors in the host environment. Furthermore, along with data collected by others, our findings shed light on the important role of mucin in the effectiveness of antibiotics toward <i>A. baumannii</i> in biotic environments where this glycoprotein is present. Taken together, these findings provide a deeper understanding of how <i>A. baumannii</i> uses a complex regulation of adherence and virulence factors in response to specific environmental signals to promote its persistence and pathogenicity within abiotic and biotic environments. 2016-11-21 English text Miami University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=miami147937747636766 http://rave.ohiolink.edu/etdc/view?acc_num=miami147937747636766 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Molecular Biology Genetics Acinetobacter baumannii biofilms motility two-component regulatory systems host-pathogen interactions mucin |
| spellingShingle |
Molecular Biology Genetics Acinetobacter baumannii biofilms motility two-component regulatory systems host-pathogen interactions mucin Ohneck, Emily Jean Interaction of <i>Acinetobacter baumannii</i> with abiotic and biotic environments |
| author |
Ohneck, Emily Jean |
| author_facet |
Ohneck, Emily Jean |
| author_sort |
Ohneck, Emily Jean |
| title |
Interaction of <i>Acinetobacter baumannii</i> with abiotic and biotic environments |
| title_short |
Interaction of <i>Acinetobacter baumannii</i> with abiotic and biotic environments |
| title_full |
Interaction of <i>Acinetobacter baumannii</i> with abiotic and biotic environments |
| title_fullStr |
Interaction of <i>Acinetobacter baumannii</i> with abiotic and biotic environments |
| title_full_unstemmed |
Interaction of <i>Acinetobacter baumannii</i> with abiotic and biotic environments |
| title_sort |
interaction of <i>acinetobacter baumannii</i> with abiotic and biotic environments |
| publisher |
Miami University / OhioLINK |
| publishDate |
2016 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=miami147937747636766 |
| work_keys_str_mv |
AT ohneckemilyjean interactionofiacinetobacterbaumanniiiwithabioticandbioticenvironments |
| _version_ |
1719440814113816576 |