CONTROLLING THE DENSITY OF DISULFIDE CROSS-LINKS IN KERATIN BIOMATERIALS FOR BONE REGENERATION: BIOACTIVITY AND MECHANISM AND DURATION OF BMP-2 DELIVERY

Bibliographic Details
Main Author:	Haque, Salma, United States
Language:	English
Published:	Miami University / OhioLINK 2015
Subjects:	Biomedical Engineering
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=miami1439295485

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-miami14392954852021-08-03T06:32:47Z CONTROLLING THE DENSITY OF DISULFIDE CROSS-LINKS IN KERATIN BIOMATERIALS FOR BONE REGENERATION: BIOACTIVITY AND MECHANISM AND DURATION OF BMP-2 DELIVERY Haque, Salma, United States Biomedical Engineering Effective methods for the treatment of bone injuries that do not heal (non-union) or heal slowly (delayed union) after reduction is a clinical challenge. The use of a collagen sponge to deliver recombinant human bone morphogenetic protein 2 (rhBMP-2) has been shown to be an effective substitute to autografts and allografts for the regeneration of new bone tissue. However, the FDA has limited its approved use to lumbar spinal fusion, open tibial fracture, and craniomaxillofacial injuries, presumably due to ectopic bone growth and other side effects that result from supraphysiological doses of rhBMP-2. Based on our previous findings in femur and mandibular defects, we explored keratin as an alternative carrier system to the existing collagen-based rhBMP-2 delivery system. We have previously used a strategy in which we modulated the levels of disulfide crosslinking in keratin hydrogels based on the extracted form of keratin. This thesis seeks to understand how rhBMP-2 delivered from the keratin hydrogels reaches to cells to achieve bioactivity. In vitro studies were conducted to assess the bioactivity of the soluble rhBMP-2 and matrix-bound rhBMP-2. rhBMP- 2 that remains associated with the keratin carrier is more bioactive than rhBMP-2 that is released from the carrier as a soluble “drug”. 2015-08-12 English text Miami University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=miami1439295485 http://rave.ohiolink.edu/etdc/view?acc_num=miami1439295485 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Biomedical Engineering
spellingShingle	Biomedical Engineering Haque, Salma, United States CONTROLLING THE DENSITY OF DISULFIDE CROSS-LINKS IN KERATIN BIOMATERIALS FOR BONE REGENERATION: BIOACTIVITY AND MECHANISM AND DURATION OF BMP-2 DELIVERY
author	Haque, Salma, United States
author_facet	Haque, Salma, United States
author_sort	Haque, Salma, United States
title	CONTROLLING THE DENSITY OF DISULFIDE CROSS-LINKS IN KERATIN BIOMATERIALS FOR BONE REGENERATION: BIOACTIVITY AND MECHANISM AND DURATION OF BMP-2 DELIVERY
title_short	CONTROLLING THE DENSITY OF DISULFIDE CROSS-LINKS IN KERATIN BIOMATERIALS FOR BONE REGENERATION: BIOACTIVITY AND MECHANISM AND DURATION OF BMP-2 DELIVERY
title_full	CONTROLLING THE DENSITY OF DISULFIDE CROSS-LINKS IN KERATIN BIOMATERIALS FOR BONE REGENERATION: BIOACTIVITY AND MECHANISM AND DURATION OF BMP-2 DELIVERY
title_fullStr	CONTROLLING THE DENSITY OF DISULFIDE CROSS-LINKS IN KERATIN BIOMATERIALS FOR BONE REGENERATION: BIOACTIVITY AND MECHANISM AND DURATION OF BMP-2 DELIVERY
title_full_unstemmed	CONTROLLING THE DENSITY OF DISULFIDE CROSS-LINKS IN KERATIN BIOMATERIALS FOR BONE REGENERATION: BIOACTIVITY AND MECHANISM AND DURATION OF BMP-2 DELIVERY
title_sort	controlling the density of disulfide cross-links in keratin biomaterials for bone regeneration: bioactivity and mechanism and duration of bmp-2 delivery
publisher	Miami University / OhioLINK
publishDate	2015
url	http://rave.ohiolink.edu/etdc/view?acc_num=miami1439295485
work_keys_str_mv	AT haquesalmaunitedstates controllingthedensityofdisulfidecrosslinksinkeratinbiomaterialsforboneregenerationbioactivityandmechanismanddurationofbmp2delivery
_version_	1719438657365999616

CONTROLLING THE DENSITY OF DISULFIDE CROSS-LINKS IN KERATIN BIOMATERIALS FOR BONE REGENERATION: BIOACTIVITY AND MECHANISM AND DURATION OF BMP-2 DELIVERY

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