STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH

STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH

Show other versions (1)
Bibliographic Details
Main Author: Tesak, Jennifer Lynn
Language:English
Published: Miami University / OhioLINK 2012
Subjects:
Chemistry
Click Chemistry
Q-VD-OPh
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=miami1337280266
id ndltd-OhioLink-oai-etd.ohiolink.edu-miami1337280266
record_format oai_dc
spelling ndltd-OhioLink-oai-etd.ohiolink.edu-miami13372802662021-08-03T05:41:42Z STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH Tesak, Jennifer Lynn Chemistry Click Chemistry Q-VD-OPh The exploitation of the copper(I)-catalyzed 1,2,3-triazole forming reaction between azides and terminal alkynes has contributed to drug discovery due to the high degree of dependability, efficiency, specificity and biocompatibility of the reactions and products. Using this well-known click chemistry reaction, a non-steroidal anti-inflammatory drug, naproxen, could possibly be coupled to an apoptosis inhibitor, Q-VD-OPh. Two synthetic routes were envisioned. The most effective click reaction was the Cu(I) catalyzed cycloaddition of naproxen propargyl ester to 4-azido-2,6-difluorophenol acetate. Characterizations of these materials were done using 1HNMR, 13CNMR, liquid chromatography mass spectrometry, and infrared spectroscopy. 2012-05-17 English text Miami University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=miami1337280266 http://rave.ohiolink.edu/etdc/view?acc_num=miami1337280266 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Chemistry
Click Chemistry
Q-VD-OPh
spellingShingle Chemistry
Click Chemistry
Q-VD-OPh
Tesak, Jennifer Lynn
STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH
author Tesak, Jennifer Lynn
author_facet Tesak, Jennifer Lynn
author_sort Tesak, Jennifer Lynn
title STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH
title_short STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH
title_full STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH
title_fullStr STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH
title_full_unstemmed STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH
title_sort study of click chemistry: working towards ‘clicking’ a non-steroidal anti-inflammatory to an apoptosis inhibitor q-vd-oph
publisher Miami University / OhioLINK
publishDate 2012
url http://rave.ohiolink.edu/etdc/view?acc_num=miami1337280266
work_keys_str_mv AT tesakjenniferlynn studyofclickchemistryworkingtowardsclickinganonsteroidalantiinflammatorytoanapoptosisinhibitorqvdoph
_version_ 1719423698332549120

Similar Items