Plasticity of Peripheral Neurons Following Axotomy of the Superior Cervical Ganglion

Plasticity of Peripheral Neurons Following Axotomy of the Superior Cervical Ganglion

Bibliographic Details
Main Author: Zhu, Zheng
Language:English
Published: Miami University / OhioLINK 2011
Subjects:
Biology
Zoology
SCG
Sympathetic
Axotomy
VEGF
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=miami1324417326
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-miami13244173262021-08-03T05:41:42Z Plasticity of Peripheral Neurons Following Axotomy of the Superior Cervical Ganglion Zhu, Zheng Biology Zoology SCG Sympathetic Axotomy VEGF The overall goal of this project was to understand the changes in peripheral neurons and their vascular targets following axotomy (transection) of sympathetic postganglionic axons arising from the superior cervical ganglion (SCG). Changes were documented at short- and long-term survival time points following the injury. At seven days following axotomy, the extracerebral blood vessels were denervated of sympathetic axons, yet sensory and parasympathetic perivascular axons were increased and decreased, respectively. Protein expression of vascular endothelial growth factor (VEGF) in the vasculature was unchanged, but VEGF was increased in the SCG as well as the trigeminal ganglion, which houses the parent cell bodies of the sensory perivascular axons. At 12 weeks, the sympathetic innervation showed some recovery, yet sensory and parasympathetic innervation remained altered, as did VEGF in the SCG and trigeminal ganglion. These results reveal the presence of long term plasticity in peripheral neurons following axotomy of the SCG. 2011 English text Miami University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=miami1324417326 http://rave.ohiolink.edu/etdc/view?acc_num=miami1324417326 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biology
Zoology
SCG
Sympathetic
Axotomy
VEGF
spellingShingle Biology
Zoology
SCG
Sympathetic
Axotomy
VEGF
Zhu, Zheng
Plasticity of Peripheral Neurons Following Axotomy of the Superior Cervical Ganglion
author Zhu, Zheng
author_facet Zhu, Zheng
author_sort Zhu, Zheng
title Plasticity of Peripheral Neurons Following Axotomy of the Superior Cervical Ganglion
title_short Plasticity of Peripheral Neurons Following Axotomy of the Superior Cervical Ganglion
title_full Plasticity of Peripheral Neurons Following Axotomy of the Superior Cervical Ganglion
title_fullStr Plasticity of Peripheral Neurons Following Axotomy of the Superior Cervical Ganglion
title_full_unstemmed Plasticity of Peripheral Neurons Following Axotomy of the Superior Cervical Ganglion
title_sort plasticity of peripheral neurons following axotomy of the superior cervical ganglion
publisher Miami University / OhioLINK
publishDate 2011
url http://rave.ohiolink.edu/etdc/view?acc_num=miami1324417326
work_keys_str_mv AT zhuzheng plasticityofperipheralneuronsfollowingaxotomyofthesuperiorcervicalganglion
_version_ 1719423681891926016

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