Organization and Evolution of the CYP2ABFGST Gene Cluster in Rat, and a Comparison with Human and Mouse

Organization and Evolution of the CYP2ABFGST Gene Cluster in Rat, and a Comparison with Human and Mouse

Bibliographic Details
Main Author: Hu, Shengyong
Language:English
Published: Miami University / OhioLINK 2005
Subjects:
CYP2ABFGST gene cluster
molecular evolution
rat
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=miami1122059268
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-miami11220592682021-08-03T05:39:43Z Organization and Evolution of the CYP2ABFGST Gene Cluster in Rat, and a Comparison with Human and Mouse Hu, Shengyong CYP2ABFGST gene cluster molecular evolution rat The evolution of gene families can be best understood by studying the modern organization and functions of family members, and by comparing parallel families in different species. As an interesting example of gene family evolution, the CYP2ABFGST gene cluster has been characterized in rat. Eighteen loci from six subfamilies have been identified by sequencing PCR-amplified exons or introns from BAC clones. The overall organization of the CYP2ABFGST cluster in rat is much more similar to the mouse than to the human cluster. The rat cluster is the simplest of the three, with genes from each subfamily in tandem. Specific loci from all three species have been extensively compared to sort out relationships between genes. These comparisons allow us to reconstruct the probable structure of the CYP2ABFGST cluster in the common ancestor of primates and rodents, and to infer a model of the evolution of this gene cluster in the three species. 2005-07-26 English text Miami University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=miami1122059268 http://rave.ohiolink.edu/etdc/view?acc_num=miami1122059268 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic CYP2ABFGST gene cluster
molecular evolution
rat
spellingShingle CYP2ABFGST gene cluster
molecular evolution
rat
Hu, Shengyong
Organization and Evolution of the CYP2ABFGST Gene Cluster in Rat, and a Comparison with Human and Mouse
author Hu, Shengyong
author_facet Hu, Shengyong
author_sort Hu, Shengyong
title Organization and Evolution of the CYP2ABFGST Gene Cluster in Rat, and a Comparison with Human and Mouse
title_short Organization and Evolution of the CYP2ABFGST Gene Cluster in Rat, and a Comparison with Human and Mouse
title_full Organization and Evolution of the CYP2ABFGST Gene Cluster in Rat, and a Comparison with Human and Mouse
title_fullStr Organization and Evolution of the CYP2ABFGST Gene Cluster in Rat, and a Comparison with Human and Mouse
title_full_unstemmed Organization and Evolution of the CYP2ABFGST Gene Cluster in Rat, and a Comparison with Human and Mouse
title_sort organization and evolution of the cyp2abfgst gene cluster in rat, and a comparison with human and mouse
publisher Miami University / OhioLINK
publishDate 2005
url http://rave.ohiolink.edu/etdc/view?acc_num=miami1122059268
work_keys_str_mv AT hushengyong organizationandevolutionofthecyp2abfgstgeneclusterinratandacomparisonwithhumanandmouse
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