THE ROLE OF ORPHANIN FQ/NOCICEPTIN IN MEDIATING THE PROLACTIN RESPONSE TO STRESS
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| Language: | English |
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Miami University / OhioLINK
2005
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=miami1118758040 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-miami1118758040 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-miami11187580402021-08-03T05:39:28Z THE ROLE OF ORPHANIN FQ/NOCICEPTIN IN MEDIATING THE PROLACTIN RESPONSE TO STRESS Derringer, Tiffany The role of OFQ/N in mediating the prolactin response to acute and repeated stress was investigated. Male and female wild type and OFQ/N knock-out mice were subjected to 5 minutes of restraint stress (acute) or 4 bouts of restraint stress at 1 hour intervals (repeated) prior to sacrifice. Plasma prolactin and corticosterone levels, as well as pituitary prolactin and estrogen receptor alpha content, were determined. There was a significant gender difference in the prolactin, but not the corticosterone, response to stress. OFQ/N mediates the prolactin response to acute stress in males, but not females. Although stress did not affect pituitary levels of prolactin, female OFQ/N knock-out mice had higher pituitary prolactin content, but not a greater stress response than wild type mice. OFQ/N does not appear to mediate pituitary estrogen receptor alpha expression. These results suggest that OFQ/N is involved in mediating the prolactin secretory response to stress in males. 2005-06-20 English text Miami University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=miami1118758040 http://rave.ohiolink.edu/etdc/view?acc_num=miami1118758040 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| author |
Derringer, Tiffany |
| spellingShingle |
Derringer, Tiffany THE ROLE OF ORPHANIN FQ/NOCICEPTIN IN MEDIATING THE PROLACTIN RESPONSE TO STRESS |
| author_facet |
Derringer, Tiffany |
| author_sort |
Derringer, Tiffany |
| title |
THE ROLE OF ORPHANIN FQ/NOCICEPTIN IN MEDIATING THE PROLACTIN RESPONSE TO STRESS |
| title_short |
THE ROLE OF ORPHANIN FQ/NOCICEPTIN IN MEDIATING THE PROLACTIN RESPONSE TO STRESS |
| title_full |
THE ROLE OF ORPHANIN FQ/NOCICEPTIN IN MEDIATING THE PROLACTIN RESPONSE TO STRESS |
| title_fullStr |
THE ROLE OF ORPHANIN FQ/NOCICEPTIN IN MEDIATING THE PROLACTIN RESPONSE TO STRESS |
| title_full_unstemmed |
THE ROLE OF ORPHANIN FQ/NOCICEPTIN IN MEDIATING THE PROLACTIN RESPONSE TO STRESS |
| title_sort |
role of orphanin fq/nociceptin in mediating the prolactin response to stress |
| publisher |
Miami University / OhioLINK |
| publishDate |
2005 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=miami1118758040 |
| work_keys_str_mv |
AT derringertiffany theroleoforphaninfqnociceptininmediatingtheprolactinresponsetostress AT derringertiffany roleoforphaninfqnociceptininmediatingtheprolactinresponsetostress |
| _version_ |
1719423166514724864 |