Neuroinflammation, Neurologic and Cognitive Deficits After Hemorrhagic Stroke in Mice with Type-I Diabetes Mellitus

Bibliographic Details
Main Author:	Bahader, Ghaith
Language:	English
Published:	University of Toledo Health Science Campus / OhioLINK 2020
Subjects:	Neurosciences Neurobiology
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=mco1595342324908659

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-mco15953423249086592021-09-02T05:10:39Z Neuroinflammation, Neurologic and Cognitive Deficits After Hemorrhagic Stroke in Mice with Type-I Diabetes Mellitus Bahader, Ghaith Neurosciences Neurobiology Intracerebral hemorrhage (ICH) is a common subtype of stroke that is associated with higher rates of mortality. Survivors from ICH are left with severe motor and cognitive deficits. Co-morbid condition, such as Diabetes Mellitus (DM) is considered a significant risk factor that increases the susceptibility of having a stroke by 2-6 times and the victims suffer from severe post-stroke injury, neurologic and cognitive dysfunctions. Although the association of diabetes with ischemic stroke has been widely studied, fewer studies have discussed the impact of DM on the outcomes of ICH injury. In our previously published study, we observed that there is a marked increase in neurologic deficits in diabetic mice compared to their relative controls after permanent ischemia. In this study, we were interested to study ICH-induced neuroinflammation, as well as neurologic and cognitive deficits in mice with DM. DM was induced by streptozotocin injection, a well-known model to induce DM and experimental ICH was induced by subjecting animals to intrastriatal collagenase injections. Our results showed that DM had negative impact on the post-stroke sensorimotor and locomotor outcomes in mice. In addition, DM mice also suffered from severe cognitive deficits, specifically on learning paradigms. The animals with DM showed higher levels of systemic inflammation relative to control groups which further precipitated in ICH-subjected DM group. Moreover, the impact of DM is mediated through neuroinflammatory but not glutamate excitatory mechanisms. This study gives insights on the influence of DM and the outcomes after ICH such as neuroinflammation, neurologic and cognitive dysfunctions. 2020 English text University of Toledo Health Science Campus / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=mco1595342324908659 http://rave.ohiolink.edu/etdc/view?acc_num=mco1595342324908659 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center.
collection	NDLTD
language	English
sources	NDLTD
topic	Neurosciences Neurobiology
spellingShingle	Neurosciences Neurobiology Bahader, Ghaith Neuroinflammation, Neurologic and Cognitive Deficits After Hemorrhagic Stroke in Mice with Type-I Diabetes Mellitus
author	Bahader, Ghaith
author_facet	Bahader, Ghaith
author_sort	Bahader, Ghaith
title	Neuroinflammation, Neurologic and Cognitive Deficits After Hemorrhagic Stroke in Mice with Type-I Diabetes Mellitus
title_short	Neuroinflammation, Neurologic and Cognitive Deficits After Hemorrhagic Stroke in Mice with Type-I Diabetes Mellitus
title_full	Neuroinflammation, Neurologic and Cognitive Deficits After Hemorrhagic Stroke in Mice with Type-I Diabetes Mellitus
title_fullStr	Neuroinflammation, Neurologic and Cognitive Deficits After Hemorrhagic Stroke in Mice with Type-I Diabetes Mellitus
title_full_unstemmed	Neuroinflammation, Neurologic and Cognitive Deficits After Hemorrhagic Stroke in Mice with Type-I Diabetes Mellitus
title_sort	neuroinflammation, neurologic and cognitive deficits after hemorrhagic stroke in mice with type-i diabetes mellitus
publisher	University of Toledo Health Science Campus / OhioLINK
publishDate	2020
url	http://rave.ohiolink.edu/etdc/view?acc_num=mco1595342324908659
work_keys_str_mv	AT bahaderghaith neuroinflammationneurologicandcognitivedeficitsafterhemorrhagicstrokeinmicewithtypeidiabetesmellitus
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Neuroinflammation, Neurologic and Cognitive Deficits After Hemorrhagic Stroke in Mice with Type-I Diabetes Mellitus

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