Determination of Early Human Intercontinental Migration from Genomic IBD segment Flow

Bibliographic Details
Main Author:	Mainsah, Joseph S.
Language:	English
Published:	University of Toledo Health Science Campus / OhioLINK 2016
Subjects:	Biomedical Research
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=mco1479319602398361

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-mco14793196023983612021-08-03T06:38:56Z Determination of Early Human Intercontinental Migration from Genomic IBD segment Flow Mainsah, Joseph S. Biomedical Research Previous research demonstrated that genomic Identity by Decent (IBD) segments are a means of revealing distant relatedness between individuals from the same or different continents. When these segments are identically shared in one or more loci between individuals from different continents the inference is that these individuals are distantly related. IBD segments are characterized by rare variant clusters (RVCs) of 5 or more very rare genetic variants (vrGVs) with minor allele frequencies >2%. Although RVCs are a means of detecting distant genetic relatedness they cannot determine the directional flow of these IBD segments between continents. My objective was to determine the directional flow of these IBD segments from continents to continent after generations of admixture and to infer human continental migratory history. To perform this task, I analyzed continental allelic frequency differences of SNPs located within IBD segments coordinates of related pairs of individuals’ genomic data. Also, the occurrence of these SNPs in homozygous and heterozygous forms between pairs of individuals when there was a statistically significant difference in the allele frequencies of these SNPs from continent to continent. This experiment comprised individuals from African and Asian populations which shared the least number of IBD segments and African and European populations. Between the African and Asian populations, there was a clear majority (85%) of IBD segments analyzed flowing from Africa to Asia versus 15% from Asia to Africa. As for the IBD segments shared between the African and European populations there was a less definite result with 57% of segments flowing from Africa to Europe and 43% in the opposite direction. Given that the median size of IBD segments found between Asian and African populations was the smallest (54kb) compared to other intercontinental population comparison, there can be a conclusion that the admixture between the African and Asian populations is the most ancient given that with every generational admixture, IBD segments reduce in size from further admixture. These results would tend to imply that there was an ancient migratory event of Africans to Asia with some back migration occurring from Asia to Africa. On the other hand, my data suggest an almost equal degree of migration between African and European populations with a little more migration from Africa to European as opposed to migration from Europe to Africa. With this method of analyzing IBD segment flow it is difficult to determine whether these migrations occurred hundreds of thousands of years ago or more recently because of external issues like recombination and mutation events which would affect IBD segments size. However, we get a general idea of migration patterns that have taken place between continents 2016 English text University of Toledo Health Science Campus / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=mco1479319602398361 http://rave.ohiolink.edu/etdc/view?acc_num=mco1479319602398361 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Biomedical Research
spellingShingle	Biomedical Research Mainsah, Joseph S. Determination of Early Human Intercontinental Migration from Genomic IBD segment Flow
author	Mainsah, Joseph S.
author_facet	Mainsah, Joseph S.
author_sort	Mainsah, Joseph S.
title	Determination of Early Human Intercontinental Migration from Genomic IBD segment Flow
title_short	Determination of Early Human Intercontinental Migration from Genomic IBD segment Flow
title_full	Determination of Early Human Intercontinental Migration from Genomic IBD segment Flow
title_fullStr	Determination of Early Human Intercontinental Migration from Genomic IBD segment Flow
title_full_unstemmed	Determination of Early Human Intercontinental Migration from Genomic IBD segment Flow
title_sort	determination of early human intercontinental migration from genomic ibd segment flow
publisher	University of Toledo Health Science Campus / OhioLINK
publishDate	2016
url	http://rave.ohiolink.edu/etdc/view?acc_num=mco1479319602398361
work_keys_str_mv	AT mainsahjosephs determinationofearlyhumanintercontinentalmigrationfromgenomicibdsegmentflow
_version_	1719440808968454144

Determination of Early Human Intercontinental Migration from Genomic IBD segment Flow

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