Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil

Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil

Bibliographic Details
Main Author: Majrad, Mohamed Saleh
Language:English
Published: University of Toledo Health Science Campus / OhioLINK 2014
Subjects:
Pharmaceuticals
Solid Lipid Nanoparticles containing 5-Fluorouracil
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=mco1404675580
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-mco14046755802021-08-03T06:25:46Z Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil Majrad, Mohamed Saleh Pharmaceuticals Solid Lipid Nanoparticles containing 5-Fluorouracil The primary goal of this research work was to develop solid lipid nanoparticles (SLNs) containing 5-Flourouracil and to evaluate its effect on various cell lines. The solid lipid nanoparticles were prepared through a new temperature modulated solidification technique developed in our laboratory. Particle size analysis by dynamic light scattering (DLS) and morphology evaluation by transmission electron microscopy (TEM) demonstrated that the SLNs are nanoparticulates. Cytotoxic activity of SLN loaded 5-Fluorouracil showed a decrease in viability when compared to pure solution of 5-FU on PC-3 and Caco-2 cell line. Blank SLN showed no decrease in cell viability when the concentration increased. Biocompatibility studies of SLNs in human RBCs indicated that 5-FU SLN formulations are compatible. Bovine permeability study shows that apparent permeability for 5-FU SLN was 0.000348 cm/s and 1.339 cm/s for 5-FU solution. The preliminary results from various in vitro evaluations suggest that 5-FU loaded SLNs have the potential to be used as an anti-cancer drug delivery system. 2014 English text University of Toledo Health Science Campus / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=mco1404675580 http://rave.ohiolink.edu/etdc/view?acc_num=mco1404675580 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Pharmaceuticals
Solid Lipid Nanoparticles containing 5-Fluorouracil
spellingShingle Pharmaceuticals
Solid Lipid Nanoparticles containing 5-Fluorouracil
Majrad, Mohamed Saleh
Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil
author Majrad, Mohamed Saleh
author_facet Majrad, Mohamed Saleh
author_sort Majrad, Mohamed Saleh
title Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil
title_short Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil
title_full Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil
title_fullStr Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil
title_full_unstemmed Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil
title_sort quantitative, qualitative and in vitro evaluation of solid lipid nanoparticles containing 5-fluorouracil
publisher University of Toledo Health Science Campus / OhioLINK
publishDate 2014
url http://rave.ohiolink.edu/etdc/view?acc_num=mco1404675580
work_keys_str_mv AT majradmohamedsaleh quantitativequalitativeandinvitroevaluationofsolidlipidnanoparticlescontaining5fluorouracil
_version_ 1719436361180643328

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