Characterization of Genomic MidRange Inhomogeneity

Characterization of Genomic MidRange Inhomogeneity

Bibliographic Details
Main Author: Bechtel, Jason M.
Language:English
Published: University of Toledo Health Science Campus / OhioLINK 2008
Subjects:
Bioinformatics
Biostatistics
Genetics
inhomogeneity
cluster
CpG island
genomic MRI
RNA secondary structures
mid-range
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=mco1217365784
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-mco12173657842021-08-03T05:38:36Z Characterization of Genomic MidRange Inhomogeneity Bechtel, Jason M. Bioinformatics Biostatistics Genetics inhomogeneity cluster CpG island genomic MRI RNA secondary structures mid-range Genomes encode many signals at multiple levels. They must therefore manifestinhomogeneity in their nucleotide composition. Inhomogeneity is identifiable from theshortrangewhere neighboring nucleotides influence the choice of base at a site, to thelongrange,commonly known as isochores, where a particular base composition can spanmillions of nucleotides. This work explores the mostly overlooked phenomenon ofgenomic midrangeinhomogeneity (MRI). MRI is defined as an interdependence betweennucleotide choice and base composition over a distance of 301000base pairs. Through theinvestigation of thousands of human genes, the results presented herein establish theexistence of MRI throughout mammalian genomes, establish a link with strong localsecondary structures and characterize the properties of MRI. A public computationalresource has been created to support further study of genomic MRI. 2008-09-02 English text University of Toledo Health Science Campus / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=mco1217365784 http://rave.ohiolink.edu/etdc/view?acc_num=mco1217365784 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center.
collection NDLTD
language English
sources NDLTD
topic Bioinformatics
Biostatistics
Genetics
inhomogeneity
cluster
CpG island
genomic MRI
RNA secondary structures
mid-range
spellingShingle Bioinformatics
Biostatistics
Genetics
inhomogeneity
cluster
CpG island
genomic MRI
RNA secondary structures
mid-range
Bechtel, Jason M.
Characterization of Genomic MidRange Inhomogeneity
author Bechtel, Jason M.
author_facet Bechtel, Jason M.
author_sort Bechtel, Jason M.
title Characterization of Genomic MidRange Inhomogeneity
title_short Characterization of Genomic MidRange Inhomogeneity
title_full Characterization of Genomic MidRange Inhomogeneity
title_fullStr Characterization of Genomic MidRange Inhomogeneity
title_full_unstemmed Characterization of Genomic MidRange Inhomogeneity
title_sort characterization of genomic midrange inhomogeneity
publisher University of Toledo Health Science Campus / OhioLINK
publishDate 2008
url http://rave.ohiolink.edu/etdc/view?acc_num=mco1217365784
work_keys_str_mv AT bechteljasonm characterizationofgenomicmidrangeinhomogeneity
_version_ 1719422965420916736

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