Neural Mechanisms Underlying Stress-Induced Depression and Its Prevention

Neural Mechanisms Underlying Stress-Induced Depression and Its Prevention

Bibliographic Details
Main Author: Nagabhushan, Sahana
Language:English
Published: Kent State University Honors College / OhioLINK 2011
Subjects:
Behavioral Sciences
depression
stress
norepinephrine
b-adrenergic receptors
propranolol
interleukin-1
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1304462392
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ksuhonors13044623922021-08-03T05:38:20Z Neural Mechanisms Underlying Stress-Induced Depression and Its Prevention Nagabhushan, Sahana Behavioral Sciences depression stress norepinephrine b-adrenergic receptors propranolol interleukin-1 Psychological and physical stressors stimulate the noradrenergic system which results in the induction of cytokine production via norepinephrine acting on β-adrenergic receptors. These cytokines, especially IL-1β, and the dysregulation of the noradrenergic system are implicated in depressive behavior. Current antidepressants increase norepinephrine in the brain which often leads to worsening of depressive symptoms during early stages of treatment. Blocking the effects of norepinephrine, with a β-adrenergic receptor blocker like Propranolol, may prevent stress-induced depression. 2011-05-26 English text Kent State University Honors College / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1304462392 http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1304462392 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Behavioral Sciences
depression
stress
norepinephrine
b-adrenergic receptors
propranolol
interleukin-1
spellingShingle Behavioral Sciences
depression
stress
norepinephrine
b-adrenergic receptors
propranolol
interleukin-1
Nagabhushan, Sahana
Neural Mechanisms Underlying Stress-Induced Depression and Its Prevention
author Nagabhushan, Sahana
author_facet Nagabhushan, Sahana
author_sort Nagabhushan, Sahana
title Neural Mechanisms Underlying Stress-Induced Depression and Its Prevention
title_short Neural Mechanisms Underlying Stress-Induced Depression and Its Prevention
title_full Neural Mechanisms Underlying Stress-Induced Depression and Its Prevention
title_fullStr Neural Mechanisms Underlying Stress-Induced Depression and Its Prevention
title_full_unstemmed Neural Mechanisms Underlying Stress-Induced Depression and Its Prevention
title_sort neural mechanisms underlying stress-induced depression and its prevention
publisher Kent State University Honors College / OhioLINK
publishDate 2011
url http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1304462392
work_keys_str_mv AT nagabhushansahana neuralmechanismsunderlyingstressinduceddepressionanditsprevention
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