Mechanistic Studies on the Reaction of Cob(I)alamin and Nitrite
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Kent State University Honors College / OhioLINK
2011
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1304454244 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-ksuhonors13044542442021-08-03T05:38:20Z Mechanistic Studies on the Reaction of Cob(I)alamin and Nitrite Plymale, Noah T. Biochemistry Chemistry Vitamin B<sub>12</sub> cob(I)alamin kinetics mechanistic nitrite reactive oxygen / nitrogen species bioinorganic chemistry hydroxylamine cob(II)alamin <p>Reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as nitrite (NO<sub>2</sub><sup>-</sup>) are small reactive molecules present naturally in biological systems. Elevated levels of ROS and RNS (oxidative / nitrosative stress) are associated with inflammatory diseases and cancer. Vitamin B<sub>12</sub>, known as cobalamin (Cbl), participates in two B<sub>12</sub>-dependent enzyme reactions in mammals that are inactivated during oxidative / nitrosative stress. Cob(I)alamin (Cbl(I)), an intermediate in the B<sub>12</sub>-dependent methionine synthase reaction and a biosynthetic precursor of the B<sub>12</sub> coenzymes, is readily oxidized to cob(II)alamin (Cbl(II)).The kinetics of the reaction between Cbl(I) and NO<sub>2</sub><sup>-</sup> have been investigated and a reaction mechanism proposed.</p> 2011-07-22 English text Kent State University Honors College / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1304454244 http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1304454244 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biochemistry Chemistry Vitamin B<sub>12</sub> cob(I)alamin kinetics mechanistic nitrite reactive oxygen / nitrogen species bioinorganic chemistry hydroxylamine cob(II)alamin |
| spellingShingle |
Biochemistry Chemistry Vitamin B<sub>12</sub> cob(I)alamin kinetics mechanistic nitrite reactive oxygen / nitrogen species bioinorganic chemistry hydroxylamine cob(II)alamin Plymale, Noah T. Mechanistic Studies on the Reaction of Cob(I)alamin and Nitrite |
| author |
Plymale, Noah T. |
| author_facet |
Plymale, Noah T. |
| author_sort |
Plymale, Noah T. |
| title |
Mechanistic Studies on the Reaction of Cob(I)alamin and Nitrite |
| title_short |
Mechanistic Studies on the Reaction of Cob(I)alamin and Nitrite |
| title_full |
Mechanistic Studies on the Reaction of Cob(I)alamin and Nitrite |
| title_fullStr |
Mechanistic Studies on the Reaction of Cob(I)alamin and Nitrite |
| title_full_unstemmed |
Mechanistic Studies on the Reaction of Cob(I)alamin and Nitrite |
| title_sort |
mechanistic studies on the reaction of cob(i)alamin and nitrite |
| publisher |
Kent State University Honors College / OhioLINK |
| publishDate |
2011 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1304454244 |
| work_keys_str_mv |
AT plymalenoaht mechanisticstudiesonthereactionofcobialaminandnitrite |
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1719422853571411968 |