The Ontogeny of the Mouse Oxytocin System and Potential Organizational Effects of Oxytocin on Intermale Aggression

The Ontogeny of the Mouse Oxytocin System and Potential Organizational Effects of Oxytocin on Intermale Aggression

Bibliographic Details
Main Author: Tamborski, Steven W.
Language:English
Published: Kent State University / OhioLINK 2014
Subjects:
Endocrinology
Biology
Developmental Biology
Behavioral Sciences
Oxytocin
Ontogeny
Mice
Mouse
Aggression
Development
Inter-male aggression
Fetal Injection
Autoradiography
qPCR
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=kent1397649029
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-kent13976490292021-08-03T06:23:49Z The Ontogeny of the Mouse Oxytocin System and Potential Organizational Effects of Oxytocin on Intermale Aggression Tamborski, Steven W. Endocrinology Biology Developmental Biology Behavioral Sciences Oxytocin Ontogeny Mice Mouse Aggression Development Inter-male aggression Fetal Injection Autoradiography qPCR Recent studies suggest that the neuropeptide oxytocin (Oxt) may be important for organizing the neural circuitry that regulates adult male aggressive behavior. Specifically, male Oxt knockout (Oxt -/-) and male Oxt receptor knockout (Oxtr -/-) mice have heightened aggressive behavior in adulthood, which is thought to be due to an absence of Oxt signaling during development. These data contrast with that from male forebrain specific Oxtr knockout mice, in which the Oxtr gene is excised 21-28 days after birth and have normal male aggressive behavior. Based on these data it has been hypothesized that fetal exposure to Oxt is necessary for normal displays of aggressive behavior in adulthood. To investigate this, initial expression of mouse Oxt and Oxtr mRNA as well as Oxtr protein was examined. Then, using the time point for Oxtr protein initial expression, a transuterine injection of an oxytocin antagonist (OTA) was administered to block fetal Oxtr signaling to examine if it modulates adult intermale aggression. Results indicate Oxtr mRNA is present before the Oxtr peptide’s expression on embryonic (E) day 16 and a sex difference in Oxt mRNA initial expression. Preliminary data from the OTA administration suggests increased adult intermale aggressive behavior in E14 injected mice. 2014-04-24 English text Kent State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=kent1397649029 http://rave.ohiolink.edu/etdc/view?acc_num=kent1397649029 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Endocrinology
Biology
Developmental Biology
Behavioral Sciences
Oxytocin
Ontogeny
Mice
Mouse
Aggression
Development
Inter-male aggression
Fetal Injection
Autoradiography
qPCR
spellingShingle Endocrinology
Biology
Developmental Biology
Behavioral Sciences
Oxytocin
Ontogeny
Mice
Mouse
Aggression
Development
Inter-male aggression
Fetal Injection
Autoradiography
qPCR
Tamborski, Steven W.
The Ontogeny of the Mouse Oxytocin System and Potential Organizational Effects of Oxytocin on Intermale Aggression
author Tamborski, Steven W.
author_facet Tamborski, Steven W.
author_sort Tamborski, Steven W.
title The Ontogeny of the Mouse Oxytocin System and Potential Organizational Effects of Oxytocin on Intermale Aggression
title_short The Ontogeny of the Mouse Oxytocin System and Potential Organizational Effects of Oxytocin on Intermale Aggression
title_full The Ontogeny of the Mouse Oxytocin System and Potential Organizational Effects of Oxytocin on Intermale Aggression
title_fullStr The Ontogeny of the Mouse Oxytocin System and Potential Organizational Effects of Oxytocin on Intermale Aggression
title_full_unstemmed The Ontogeny of the Mouse Oxytocin System and Potential Organizational Effects of Oxytocin on Intermale Aggression
title_sort ontogeny of the mouse oxytocin system and potential organizational effects of oxytocin on intermale aggression
publisher Kent State University / OhioLINK
publishDate 2014
url http://rave.ohiolink.edu/etdc/view?acc_num=kent1397649029
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AT tamborskistevenw ontogenyofthemouseoxytocinsystemandpotentialorganizationaleffectsofoxytocinonintermaleaggression
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