A Prospective Examination of the Effects of Obesity on Cerebral Perfusion and Cognition in Heart Failure
| Main Author: | |
|---|---|
| Language: | English |
| Published: |
Kent State University / OhioLINK
2015
|
| Subjects: | |
| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=kent1395155368 |
| id |
ndltd-OhioLink-oai-etd.ohiolink.edu-kent1395155368 |
|---|---|
| record_format |
oai_dc |
| spelling |
ndltd-OhioLink-oai-etd.ohiolink.edu-kent13951553682021-08-03T06:22:50Z A Prospective Examination of the Effects of Obesity on Cerebral Perfusion and Cognition in Heart Failure Alosco, Michael L. Neurosciences Psychology Medicine Aging Heart failure obesity body mass index cognitive function cerebral blood flow Cognitive impairment is common in heart failure (HF) and proposed to stem from reduced cerebral blood flow subsequent to the effects of cardiac dysfunction and comorbid medical conditions. Obesity is found in up to 40% of HF patients and is a known contributor to cognitive dysfunction and decreased cerebral blood flow. However, no study has simultaneously examined whether increases in body mass index (BMI) over time corresponds to accelerated cerebral hypoperfusion and cognitive decline. The current study sought to determine whether changes in BMI predicted cerebral perfusion and cognitive function over a 12-month period in HF patients. 122 HF patients were administered a cognitive battery that assessed global cognition, attention/executive function, memory, and language. Participants also completed transcranial Doppler ultrasonography to quantify cerebral blood flow (CBF). These procedures were repeated at 3- and 12-months. At baseline, 45.9% of the sample had a BMI consistent with obesity, which remained stable over time. Latent growth curve modeling (LGM) showed good model fit for improvements in global cognition and memory and declines in CBF over time. However, change in both BMI and CBF over time did not emerge as predictors of these trajectories. Cross-sectional analyses at each time point also showed no association between BMI with cognitive function and CBF. Follow-up analyses revealed a trend between better baseline treatment adherence and improved global cognitive function. In sum, BMI was not predictive of cognitive decline or reduced CBF over a 12-month period. In contrast, the observed cognitive improvements might be related to better treatment adherence. CBF also declined over time and prospective studies with extended follow-ups (e.g., 2-5 years) should clarify whether continued reductions of cerebral blood flow leads to cognitive worsening. 2015-07-02 English text Kent State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=kent1395155368 http://rave.ohiolink.edu/etdc/view?acc_num=kent1395155368 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Neurosciences Psychology Medicine Aging Heart failure obesity body mass index cognitive function cerebral blood flow |
| spellingShingle |
Neurosciences Psychology Medicine Aging Heart failure obesity body mass index cognitive function cerebral blood flow Alosco, Michael L. A Prospective Examination of the Effects of Obesity on Cerebral Perfusion and Cognition in Heart Failure |
| author |
Alosco, Michael L. |
| author_facet |
Alosco, Michael L. |
| author_sort |
Alosco, Michael L. |
| title |
A Prospective Examination of the Effects of Obesity on Cerebral Perfusion and Cognition in Heart Failure |
| title_short |
A Prospective Examination of the Effects of Obesity on Cerebral Perfusion and Cognition in Heart Failure |
| title_full |
A Prospective Examination of the Effects of Obesity on Cerebral Perfusion and Cognition in Heart Failure |
| title_fullStr |
A Prospective Examination of the Effects of Obesity on Cerebral Perfusion and Cognition in Heart Failure |
| title_full_unstemmed |
A Prospective Examination of the Effects of Obesity on Cerebral Perfusion and Cognition in Heart Failure |
| title_sort |
prospective examination of the effects of obesity on cerebral perfusion and cognition in heart failure |
| publisher |
Kent State University / OhioLINK |
| publishDate |
2015 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=kent1395155368 |
| work_keys_str_mv |
AT aloscomichaell aprospectiveexaminationoftheeffectsofobesityoncerebralperfusionandcognitioninheartfailure AT aloscomichaell prospectiveexaminationoftheeffectsofobesityoncerebralperfusionandcognitioninheartfailure |
| _version_ |
1719435722685939712 |