Sleep Impairment in Persons with Known Heart Disease: the Role of Cytokines
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Kent State University / OhioLINK
2011
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=kent1323280677 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-kent13232806772021-08-03T05:37:44Z Sleep Impairment in Persons with Known Heart Disease: the Role of Cytokines Hammonds, Tracy Lynn Psychobiology cardiovascular disease heart disease sleep impairment inflammation cytokines Increased sleep impairment is a common symptom of cardiovascular disease, and can contribute to difficulty with normal activities of living. One explanation for the increased sleep impairment observed in persons with cardiovascular disease is the presence of chronic, low-level inflammation. Cytokines are neuroimmunomodulating cells that can signal various physiological processes, such as sleep. Cytokines are secreted in abundance by immune cells as well as epithelial cells, and are thought to be secreted in low-levels in people with cardiovascular disease, thus leading to sustained inflammation. This study investigated the association between cytokine levels as well as t-helper type 1 (Th1) to t-helper type 2 (Th2) ratio and factors of sleep in patients who were diagnosed with cardiovascular disease. Ninety-six participants recruited from a cardiovascular rehabilitation program were asked to complete the Pittsburgh Quality Sleep Index (PSQI) and to undergo a venous blood draw within the first two weeks of rehabilitation. Analysis of Covariance (ANCOVA) revealed that participants who reported an inability to get to sleep within 30 minutes had higher blood plasma concentrations of IL-10 (M = 1.52, SD = 0.54 versus M = 1.24, SD = 0.46, F (1,69) = 4.48, p = .038) and TNF-α (M = 2.14, SD = .61 versus M = 1.78, SD = .71, F (1, 69) = 4.70, p = .034). In addition, TNF-α to IL-4 ratio in blood plasma was increased in participants reporting an inability to fall asleep within 30 minutes when compared to participants who reported that they fell asleep within 30 minutes (M = 1.40, SD = .572 versus M = 1.16, SD = .555, F (1, 63) = 5.81, p = .019). Multiple regression analysis revealed that IFN-γ was positively correlated with sleep duration (B = .466, p = .038). In conclusion, this study provides evidence that sleep impairment may be a result of chronic inflammation in patients with heart disease. Future research is indicated to understand the causal relationship between sleep and inflammation. In addition, further study of Th1/Th2 balance is necessary in order to provide better treatment options for sleep impairments in people with chronic inflammatory conditions. 2011 English text Kent State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=kent1323280677 http://rave.ohiolink.edu/etdc/view?acc_num=kent1323280677 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Psychobiology cardiovascular disease heart disease sleep impairment inflammation cytokines |
| spellingShingle |
Psychobiology cardiovascular disease heart disease sleep impairment inflammation cytokines Hammonds, Tracy Lynn Sleep Impairment in Persons with Known Heart Disease: the Role of Cytokines |
| author |
Hammonds, Tracy Lynn |
| author_facet |
Hammonds, Tracy Lynn |
| author_sort |
Hammonds, Tracy Lynn |
| title |
Sleep Impairment in Persons with Known Heart Disease: the Role of Cytokines |
| title_short |
Sleep Impairment in Persons with Known Heart Disease: the Role of Cytokines |
| title_full |
Sleep Impairment in Persons with Known Heart Disease: the Role of Cytokines |
| title_fullStr |
Sleep Impairment in Persons with Known Heart Disease: the Role of Cytokines |
| title_full_unstemmed |
Sleep Impairment in Persons with Known Heart Disease: the Role of Cytokines |
| title_sort |
sleep impairment in persons with known heart disease: the role of cytokines |
| publisher |
Kent State University / OhioLINK |
| publishDate |
2011 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=kent1323280677 |
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