Developmental Effects of Estrogen on the Superior Cervical Ganglion and Hypertension

Developmental Effects of Estrogen on the Superior Cervical Ganglion and Hypertension

Bibliographic Details
Main Author: Chiappini-Williamson, Christine
Language:English
Published: Kent State University / OhioLINK 2009
Subjects:
Biology
Estrogen
development
superior cervical ganglion
hypertension
SHR
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=kent1239913805
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-kent12399138052021-08-03T05:36:49Z Developmental Effects of Estrogen on the Superior Cervical Ganglion and Hypertension Chiappini-Williamson, Christine Biology Estrogen development superior cervical ganglion hypertension SHR Essential hypertension is a multi factorial disease characterized by persistent resting blood pressure (bp) above 140/90mmHg affecting approximately 33% of adult Americans. The spontaneously hypertensive rat (SHR) is the model strain and exhibits systolic pressure greater than 200mmHg with increased sympathetic activity. The superior cervical ganglion (SCG) of the SHR contains more neurons than that of the Wistar-Kyoto (WKY) control. This strain difference develops early in the neonatal period in a pattern similar to that of neuronal sex differences in the SCG of the Sprague-Dawley strain. Sex differences in neuron number develop in the Sprague-Dawley by postnatal day 15 (P15) and can be manipulated by estrogen and aromatizable androgens. The purpose of this dissertation was to confirm the presence of strain differences, establish the presence of sex differences in neuron number and determine the age of onset as well as determine the effect of neonatal aromatase blockade on adult neuron number and bp in the SHR and WKY. Cell counts were performed on 6μ paraffin sections stained with toluidine blue using the physical dissector method in ganglia from untreated P15 and adult SHR and WKY male and female rats. Estrogen synthesis was blocked by administration of a chemical aromatase inhibitor to male SHR and WKY rats from the day of birth t P15. Pups were raised by their mothers until sacrifice at 8wks of age following the measurement of bp. The SCG was removed and neurons counted by the same method. No strain differences in neuron number were found at any age in untreated animals. Sex differences were found in adult ganglia of both strains but not in either strain prior to P15. Neonatal aromatase blockade successfully reduced both bp and neuron number in males of both strains. Therefore it was concluded that there are not strain differences in SHR and WKY neuron number at any age, adult sex differences are present but do not develop prior to p15 and estrogen does play a role in the establishment of neuron number and blood pressure in both of these strains. 2009-04-17 English text Kent State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=kent1239913805 http://rave.ohiolink.edu/etdc/view?acc_num=kent1239913805 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biology
Estrogen
development
superior cervical ganglion
hypertension
SHR
spellingShingle Biology
Estrogen
development
superior cervical ganglion
hypertension
SHR
Chiappini-Williamson, Christine
Developmental Effects of Estrogen on the Superior Cervical Ganglion and Hypertension
author Chiappini-Williamson, Christine
author_facet Chiappini-Williamson, Christine
author_sort Chiappini-Williamson, Christine
title Developmental Effects of Estrogen on the Superior Cervical Ganglion and Hypertension
title_short Developmental Effects of Estrogen on the Superior Cervical Ganglion and Hypertension
title_full Developmental Effects of Estrogen on the Superior Cervical Ganglion and Hypertension
title_fullStr Developmental Effects of Estrogen on the Superior Cervical Ganglion and Hypertension
title_full_unstemmed Developmental Effects of Estrogen on the Superior Cervical Ganglion and Hypertension
title_sort developmental effects of estrogen on the superior cervical ganglion and hypertension
publisher Kent State University / OhioLINK
publishDate 2009
url http://rave.ohiolink.edu/etdc/view?acc_num=kent1239913805
work_keys_str_mv AT chiappiniwilliamsonchristine developmentaleffectsofestrogenonthesuperiorcervicalganglionandhypertension
_version_ 1719422508145311744

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