Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography

Bibliographic Details
Main Author:	Badipatla, Visweswararao
Language:	English
Published:	Cleveland State University / OhioLINK 2011
Subjects:	Analytical Chemistry
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=csu1315507284

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-csu13155072842021-08-03T05:35:19Z Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography Badipatla, Visweswararao Analytical Chemistry The current United States Pharmacopoeia (USP) test for tablet and encapsulated drug disintegration does not specify the initial disintegration time and provides limited information on the disintegration process itself. An isothermal Thermal Mechanical Analysis (IsoTMA) method is presented to measure the rate and initial time of drug disintegration, that is, the mechanical collapse of the gelatin capsule or the solid tablet. This method monitors changes in the dimensions of the formulated drugs during their disintegration in a liquid. Dimensional changes can be followed as a function of time, temperature, applied stress and pH. Some of the drugs studied were Olanzapine®, Ritalin® Amoxicillin® and .Graphical representations of their dimensional changes over time were compared for tablets and capsules from 25°C to 37°C and pH 3 to 7. An increase in temperature decreases the overall disintegration time and increases the rate of disintegration (mm/min). For Abilify®, pH had an appreciable effect on the rate of disintegration. 2011-12-01 English text Cleveland State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=csu1315507284 http://rave.ohiolink.edu/etdc/view?acc_num=csu1315507284 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Analytical Chemistry
spellingShingle	Analytical Chemistry Badipatla, Visweswararao Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography
author	Badipatla, Visweswararao
author_facet	Badipatla, Visweswararao
author_sort	Badipatla, Visweswararao
title	Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography
title_short	Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography
title_full	Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography
title_fullStr	Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography
title_full_unstemmed	Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography
title_sort	disintegration of tablets and capsules measured by isothermal thermal mechanical analysis and macrophotography
publisher	Cleveland State University / OhioLINK
publishDate	2011
url	http://rave.ohiolink.edu/etdc/view?acc_num=csu1315507284
work_keys_str_mv	AT badipatlavisweswararao disintegrationoftabletsandcapsulesmeasuredbyisothermalthermalmechanicalanalysisandmacrophotography
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Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography

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