RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT

RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT

Bibliographic Details
Main Author: Shuster, Jaime Lynn
Language:English
Published: Cleveland State University / OhioLINK 2011
Subjects:
Animals
Animal Sciences
Biochemistry
Biology
Experimental Psychology
Psychobiology
Psychology
Traumatic Brain Injury (TBI)
Sleep deprivation
Sensorimotor
Controlled Cortical Impact (CCI)
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=csu1301676196
id ndltd-OhioLink-oai-etd.ohiolink.edu-csu1301676196
record_format oai_dc
spelling ndltd-OhioLink-oai-etd.ohiolink.edu-csu13016761962021-08-03T05:35:19Z RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT Shuster, Jaime Lynn Animals Animal Sciences Biochemistry Biology Experimental Psychology Psychobiology Psychology Traumatic Brain Injury (TBI) Sleep deprivation Sensorimotor Controlled Cortical Impact (CCI) Traumatic brain injury (TBI) resulting from bomb blasts and explosions is common among military personnel. The effects of Rapid Eye Movement (REM) sleep deprivation on the sensorimotor behavior and physiological mechanisms related to TBI are unknown. Thirty-two Long Evans rats were randomly assigned to REM sleep deprivation (RSD) with controlled cortical impact (CCI), social isolation (SI) with CCI, or normal housing (NH) with CCI or Sham. Two behavioral tasks [beam walk and bilateral tactile adhesive removal somatosensory (BTARS)] testing motor and sensory function were used to investigate recovery of function. Brain tissue was analyzed using Cresyl Violet stain (cell bodies), GFAP (astrocytes) and Fluoro Jade-B (dying cells) labeling. Results indicated that 24 hour RSD immediately prior to CCI impaired recovery of sensorimotor function when tested on the adhesive removal task. Recovery of sensorimotor function as a result of 24 hour RSD immediately prior to CCI was not significantly impaired when tested on the balance beam walk task. Results also indicated that sleep deprivation seemed to intensify inflammation, lesion size and neuron loss when compared to non sleep deprived animals. 2011-04-19 English text Cleveland State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=csu1301676196 http://rave.ohiolink.edu/etdc/view?acc_num=csu1301676196 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center.
collection NDLTD
language English
sources NDLTD
topic Animals
Animal Sciences
Biochemistry
Biology
Experimental Psychology
Psychobiology
Psychology
Traumatic Brain Injury (TBI)
Sleep deprivation
Sensorimotor
Controlled Cortical Impact (CCI)
spellingShingle Animals
Animal Sciences
Biochemistry
Biology
Experimental Psychology
Psychobiology
Psychology
Traumatic Brain Injury (TBI)
Sleep deprivation
Sensorimotor
Controlled Cortical Impact (CCI)
Shuster, Jaime Lynn
RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT
author Shuster, Jaime Lynn
author_facet Shuster, Jaime Lynn
author_sort Shuster, Jaime Lynn
title RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT
title_short RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT
title_full RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT
title_fullStr RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT
title_full_unstemmed RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT
title_sort recovery of sensorimotor function in rats following acute rapid eye movement sleep deprivation and controlled cortical impact
publisher Cleveland State University / OhioLINK
publishDate 2011
url http://rave.ohiolink.edu/etdc/view?acc_num=csu1301676196
work_keys_str_mv AT shusterjaimelynn recoveryofsensorimotorfunctioninratsfollowingacuterapideyemovementsleepdeprivationandcontrolledcorticalimpact
_version_ 1719422123249762304

Similar Items