Flexible Body-Conformal Ultrasound Systems for Autonomous Image-Guided Neuromodulation

Flexible Body-Conformal Ultrasound Systems for Autonomous Image-Guided Neuromodulation

Bibliographic Details
Main Author: Pashaei, Vida
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2021
Subjects:
Biomedical Engineering
Electrical Engineering
Medical Imaging
Neurosciences
Acoustics
Radiology
Systems Design
Health Care
Wearable Biomedical Devices
Flexible Ultrasound Arrays
Image-Guided Therapy
Acoustic Neuromodulation
Ultrasound Systems
Closed-Loop Systems
Flexible Electronics
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1621006180331273
id ndltd-OhioLink-oai-etd.ohiolink.edu-case1621006180331273
record_format oai_dc
collection NDLTD
language English
sources NDLTD
topic Biomedical Engineering
Electrical Engineering
Medical Imaging
Neurosciences
Acoustics
Radiology
Systems Design
Health Care
Wearable Biomedical Devices
Flexible Ultrasound Arrays
Image-Guided Therapy
Acoustic Neuromodulation
Ultrasound Systems
Closed-Loop Systems
Flexible Electronics
spellingShingle Biomedical Engineering
Electrical Engineering
Medical Imaging
Neurosciences
Acoustics
Radiology
Systems Design
Health Care
Wearable Biomedical Devices
Flexible Ultrasound Arrays
Image-Guided Therapy
Acoustic Neuromodulation
Ultrasound Systems
Closed-Loop Systems
Flexible Electronics
Pashaei, Vida
Flexible Body-Conformal Ultrasound Systems for Autonomous Image-Guided Neuromodulation
author Pashaei, Vida
author_facet Pashaei, Vida
author_sort Pashaei, Vida
title Flexible Body-Conformal Ultrasound Systems for Autonomous Image-Guided Neuromodulation
title_short Flexible Body-Conformal Ultrasound Systems for Autonomous Image-Guided Neuromodulation
title_full Flexible Body-Conformal Ultrasound Systems for Autonomous Image-Guided Neuromodulation
title_fullStr Flexible Body-Conformal Ultrasound Systems for Autonomous Image-Guided Neuromodulation
title_full_unstemmed Flexible Body-Conformal Ultrasound Systems for Autonomous Image-Guided Neuromodulation
title_sort flexible body-conformal ultrasound systems for autonomous image-guided neuromodulation
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2021
url http://rave.ohiolink.edu/etdc/view?acc_num=case1621006180331273
work_keys_str_mv AT pashaeivida flexiblebodyconformalultrasoundsystemsforautonomousimageguidedneuromodulation
_version_ 1719458449720344576
spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case16210061803312732021-08-03T07:17:27Z Flexible Body-Conformal Ultrasound Systems for Autonomous Image-Guided Neuromodulation Pashaei, Vida Biomedical Engineering Electrical Engineering Medical Imaging Neurosciences Acoustics Radiology Systems Design Health Care Wearable Biomedical Devices Flexible Ultrasound Arrays Image-Guided Therapy Acoustic Neuromodulation Ultrasound Systems Closed-Loop Systems Flexible Electronics The interest in acoustic neuromodulation, which relies on the use of low-intensity focused ultrasound (FUS) to stimulate or inhibit neural networks, has rapidly increased due to its potential for non-invasive, portable, and low-cost treatment of various neurological disorders with sufficient spatial resolution and penetration depth. For example, the possibility of using FUS for vagus or tibial nerve modulation has the potential to provide effective treatment of disorders such as epilepsy, potentially chronic heart failure, and psychiatric conditions while avoiding the well-known side effects of implanted modulation electrodes, which include voice alterations and dyspnea. However, current FUS systems have several drawbacks limiting their broad application. First, current systems lack an integrated, portable, and low-cost imaging system with enough resolution to find the appropriate position and focal depth for modulation. Second, the relative size, weight, and power (SWaP) of current systems are restrictive for broad adoption. Third, a highly trained technician is required to control the position and angle of the ultrasound probe and to analyze the images produced by these systems. Fourth, there is high variability among users making ultrasound imaging and modulation challenging for broader use.In this work, the design and implementation of a flexible body-conformal ultrasound system for closed-loop image-guided acoustic neuromodulation are presented. The system uses ultrasound for localization and focused modulation of a specific neural system. The developed ultrasound probe integrates two flexible sub-arrays of ultrasound transducers within a single lightweight, wearable device. A 16-element array of piezoelectric transducers is developed for focused modulation of the nerve, and a second 64-element array is integrated on the probe for neural imaging and localization. Subsequently, an active version of the flexible probe is developed, including solid-state switches for onboard multiplexing. Active pre-amplifier circuits are integrated to eliminate the signal-to-noise ratio (SNR) loss due to the use of long cables, thus improving the sensitivity for localizing small body organs such as blood vessels. A strain sensor is integrated into the wearable probe to measure the curvature and provide real-time feedback for focusing and image processing. A 64-channel custom ultrasound test-bench is developed with a miniaturized transceiver and system-on-chip (SoC)-based digital back-end to be interfaced with the flexible probes and improve the image quality of the proposed image-guided neuromodulation system (e.g., by using energy-efficient plane-wave imaging). For automatic nerve localization, first, a template-matching algorithm is implemented to locate the modulation target within each 2D ultrasound image frame. Next, a deep learning method is developed to robustly localize the neuromodulation target in acquired images and provide feedback to the user, thus reducing errors caused by target movement or subject-to-subject variability. Finally, a closed-loop system is developed for real-time image-guided acoustic neuromodulation and pressure beam optimization. The in-vitro operation of the system confirms the functionality of the proposed method. 2021-06-21 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1621006180331273 http://rave.ohiolink.edu/etdc/view?acc_num=case1621006180331273 restricted--full text unavailable until 2023-05-30 This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.

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