Single-chain insulin analogs as ultra-stable therapeutics and as models of protein (mis)folding: stability, structure, dynamics, and function of novel analogs

Single-chain insulin analogs as ultra-stable therapeutics and as models of protein (mis)folding: stability, structure, dynamics, and function of novel analogs

Bibliographic Details
Main Author:	Glidden, Michael D., II
Language:	English
Published:	Case Western Reserve University School of Graduate Studies / OhioLINK 2018
Subjects:	Biophysics Biochemistry single-chain insulin analog hormone diabetes mellitus protein engineering protein stability protein structure and folding protein dynamics nuclear magnetic resonance single-chain insulin pharmacology
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=case1522270994798884

Similar Items

Structural principles of insulin formulation and analog design: A century of innovation
by: Mark A. Jarosinski, et al.
Published: (2021-10-01)

Folding And Stability Of Thymidylate Synthase : Studies Involving The Dimer Interface
by: Prasanna, V
Published: (2013)

The (Un)Folding of Multidomain Proteins Through the Lens of Single-molecule Force-spectroscopy and Computer Simulation
by: Scholl, Zackary Nathan
Published: (2016)

Evidence for a role of the multifunctional calcium/calmodulin-dependent protein kinase II in insulin secretion
by: Wenham, Robert M. (Robert Michael)
Published: (1993)

Oxidative Folding in Bacteria: Studies Using Single Molecule Force Spectroscopy
by: Kahn, Thomas
Published: (2016)

Characterization of functional disordered regions within chromatin-associated proteins
by: Catherine A. Musselman, et al.
Published: (2021-02-01)

Insulin analogs and cancer
by: Laura eSciacca, et al.
Published: (2012-02-01)

Single-Molecule Spectroscopy And Imaging Studies Of Protein Folding-Unfolding Conformational Dynamics: The Multiple-State And Multiple-Channel Energy Landscape
by: Wang, Zijian
Published: (2016)

Post-synaptic Density Disc Large Zo-1 (PDZ) Domains : From Folding and Binding to Drug Targeting
by: Chi, Celestine
Published: (2010)

Protein folding without loops and charges
by: Kurnik, Martin
Published: (2012)

Protein unfolding mechanisms and their effects on folding experiments [version 1; referees: 2 approved]
by: Lisa J Lapidus
Published: (2017-09-01)

Advances in the Multi-Orthogonal Folding of Single Polymer Chains into Single-Chain Nanoparticles
by: Agustín Blazquez-Martín, et al.
Published: (2021-01-01)

Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids
by: Huaying Zhao, et al.
Published: (2021-06-01)

Structure-Function Relationships at a Hormone-Receptor Interface: Insulin Residues B24 and B26
by: Pandyarajan, Vijay
Published: (2014)

Protein Folding & Dynamics Using Multi-scale Computational Methods
Published: (2014)

Management of diabetic ketoacidosis: Role of Rapid Acting Insulin Analogs in comparison to regular intravenous insulin.
by: Ibrar Ahmed, et al.
Published: (2021-03-01)

Sequence and Structure Based Protein Folding Studies With Implications
by: WATHEN, BRENT
Published: (2011)

Next Generation Methods for Single-Molecule Force Spectroscopy on Polyproteins and Receptor-Ligand Complexes
by: Byeongseon Yang, et al.
Published: (2020-05-01)

NMR studies of protein dynamics and structure
by: Ådén, Jörgen
Published: (2010)

Protein Folding and DNA Origami
by: Seibert, Mark Marvin
Published: (2010)

Intrinsic Local Balancing of Hydrophobic and Hydrophilic Residues in Folded Protein Sequences
by: Borukhovich, Ian
Published: (2015)

Modeling protein folding in vivo
by: Irina Sorokina, et al.
Published: (2018-07-01)

Minimalist models of proteins : misfolding and folding affinity
by: Locker, C. Rebecca
Published: (2009)

Protein fold evolution on completed genomes : distinguishing between young and old folds
by: Abeln, Sanne
Published: (2007)

Analyzing the Sequence-Stability Landscape of the Four-helix Bundle Protein Rop: Developing High-Throughput Approaches for Combinatorial Biophysics and Protein Engineering
by: Lavinder, Jason James
Published: (2009)

Structural Lessons From the Mutant Proinsulin Syndrome
by: Balamurugan Dhayalan, et al.
Published: (2021-09-01)

An energy landscaping approach to the protein folding problem
by: Sapsaman, Temsiri
Published: (2010)

Using single molecule magnetic tweezers to dissect titin energy release during muscle contraction
by: Eckels, Edward Charles
Published: (2019)

Leucine content of dietary proteins is a determinant of postprandial skeletal muscle protein synthesis in adult rats
by: Norton Layne E, et al.
Published: (2012-07-01)

Roles of OB-Fold Proteins in Replication Stress
by: Dinh-Duc Nguyen, et al.
Published: (2020-09-01)

Confocal Spectroscopy to Study Dimerization, Oligomerization and Aggregation of Proteins: A Practical Guide
by: Yann Gambin, et al.
Published: (2016-04-01)

A Comprehensive In-Silico Analysis of Deleterious Missense SNPs in Human Trehalase Gene: Gaining an Interactome Insights into Type 2 Diabetes Mellitus
by: Asura Khanam Lisa, et al.
Published: (2020-08-01)

Obesity Status Affects the Relationship Between Protein Intake and Insulin Sensitivity in Late Pregnancy
by: Brittany R. Allman, et al.
Published: (2019-09-01)

The folding kinetics of ribonuclease Sa and a charge-reversal variant
by: Trefethen, Jared M.
Published: (2005)

The Complex Role of Sequence and Structure in the Stability and Function of the TIM Barrel Proteins
by: Chan, Yvonne H.
Published: (2017)

Using ultra-rapid insulin analogs in children and adolescents with type 1 diabetes mellitus
by: О.V. Bolshova, et al.
Published: (2017-11-01)

An intrabody specific for the nucleophosmin carboxy-terminal mutant and fused to a nuclear localization sequence binds its antigen but fails to relocate it in the nucleus
by: Chiara Martinelli, et al.
Published: (2014-09-01)

Visualizing Invisibles with Single-molecule Techniques: from Protein Folding to Clinical Applications
by: Mazouchi, Amir Mohammad
Published: (2013)

Visualizing Invisibles with Single-molecule Techniques: from Protein Folding to Clinical Applications
by: Mazouchi, Amir Mohammad
Published: (2013)

Structural And Functional Analysis Of Proteins With The Double Stranded β-helix (Cupin) Domains
by: Rajavel, M
Published: (2010)

Cannot write session to /tmp/vufind_sessions/sess_8708rsdq4k1j8i5n9g5ed68jqg