Partial Volume Quantification Using Magnetic Resonance Fingerprinting
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Case Western Reserve University School of Graduate Studies / OhioLINK
2017
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=case1491572611420032 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-case14915726114200322021-08-03T07:01:32Z Partial Volume Quantification Using Magnetic Resonance Fingerprinting Deshmane, Anagha Vishwas Engineering Biomedical Engineering Medical Imaging Radiology magnetic resonance imaging quantitative imaging partial volume absolute quantification proton density mapping subvoxel analysis tissue characterization tissue quantification magnetic resonance fingerprinting Magnetic resonance imaging (MRI) is a key clinical tool which allows for imaging of biological tissues with large field-of-view, millimeter resolution, and good soft tissue contrast, without exposing the patient to ionizing radiation. Magnetic Resonance Fingerprinting (MRF) is a quantitative MRI method which pairs pseudorandom magnetization excitations and fast image acquisition with dictionary-based reconstruction for simultaneous mapping of multiple tissue and experimental properties, including T1, T2, and off-resonance, from a single experiment performed within a clinically feasible scan time. MRF signal evolutions vary in shape for different combinations of encoded properties. Like other quantitative MRI methods, MRF maps yield quantitative maps in which properties are averaged over the voxel dimensions. However, in the presence of partial volumes, voxel-averaged properties are insufficient to quantitatively assess tissue characteristics such as the potential presence of pathology. It is therefore necessary to quantify both tissue properties and voxel composition. The uniqueness of signal evolutions emanating from different tissue types in MRF allows for both tissue property mapping as well as quantification of partial volumes from the same measurement. In this dissertation, two approaches to partial volume quantification by MR Fingerprinting (PV-MRF) are quantitatively assessed for accuracy in the presence of artifacts and model errors. Applications of PV-MRF are also explored, including segmentation of pathology, improved synthetic imaging, and absolute quantification of sub-voxel tissue species. 2017-06-02 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1491572611420032 http://rave.ohiolink.edu/etdc/view?acc_num=case1491572611420032 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Engineering Biomedical Engineering Medical Imaging Radiology magnetic resonance imaging quantitative imaging partial volume absolute quantification proton density mapping subvoxel analysis tissue characterization tissue quantification magnetic resonance fingerprinting |
| spellingShingle |
Engineering Biomedical Engineering Medical Imaging Radiology magnetic resonance imaging quantitative imaging partial volume absolute quantification proton density mapping subvoxel analysis tissue characterization tissue quantification magnetic resonance fingerprinting Deshmane, Anagha Vishwas Partial Volume Quantification Using Magnetic Resonance Fingerprinting |
| author |
Deshmane, Anagha Vishwas |
| author_facet |
Deshmane, Anagha Vishwas |
| author_sort |
Deshmane, Anagha Vishwas |
| title |
Partial Volume Quantification Using Magnetic Resonance Fingerprinting |
| title_short |
Partial Volume Quantification Using Magnetic Resonance Fingerprinting |
| title_full |
Partial Volume Quantification Using Magnetic Resonance Fingerprinting |
| title_fullStr |
Partial Volume Quantification Using Magnetic Resonance Fingerprinting |
| title_full_unstemmed |
Partial Volume Quantification Using Magnetic Resonance Fingerprinting |
| title_sort |
partial volume quantification using magnetic resonance fingerprinting |
| publisher |
Case Western Reserve University School of Graduate Studies / OhioLINK |
| publishDate |
2017 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=case1491572611420032 |
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AT deshmaneanaghavishwas partialvolumequantificationusingmagneticresonancefingerprinting |
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