Associations Between Cardiac Troponin, Mechanism of Myocardial Injury, and Long-Term Mortality After Non-Cardiac Vascular Surgery

Associations Between Cardiac Troponin, Mechanism of Myocardial Injury, and Long-Term Mortality After Non-Cardiac Vascular Surgery

Bibliographic Details
Main Author: Reed, Grant William
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2017
Subjects:
Health Care
Health
Medicine
myocardial infarction
myocardial injury
Type 1 MI
Type 2 MI
troponin
peri-operative myocardial injury
non-cardiac surgery
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1491571890479287
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case14915718904792872021-08-03T07:01:32Z Associations Between Cardiac Troponin, Mechanism of Myocardial Injury, and Long-Term Mortality After Non-Cardiac Vascular Surgery Reed, Grant William Health Care Health Medicine myocardial infarction myocardial injury Type 1 MI Type 2 MI troponin peri-operative myocardial injury non-cardiac surgery It is unknown if long-term mortality after non-cardiac surgery differs by mechanism of myocardial injury. To assess this, 12,882 patients were assessed for cTnT sampling within 96-hours of vascular surgery. On Cox proportional hazards analysis, mortality was higher with any detectable cTnT compared to <0.01 ng/ml; cTnT 0.01-0.029 ng/ml (hazard ratio [HR] 1.54, 95% confidence interval [CI] 1.18-2.00), 0.03-0.099 ng/ml (HR 1.86, 95% CI 1.49-2.31), 0.10-0.399 ng/ml (HR 1.83, 95% CI 1.46-2.31), and >=0.40 ng/ml (HR 2.62, 95% CI 2.06-3.32). Compared to normal cTnT, baseline cTnT elevation was associated with increased mortality (HR 1.71, 95% CI 1.31-2.24), as were Type 2 myocardial infarction (MI) (HR 1.88, 95% CI 1.57-2.24), and Type 1 MI (HR 2.56, 95% CI 2.56, 1.82-3.60). Survival did not differ between mechanisms on Kaplan-Meier analysis. In conclusion, any detectable cTnT >=0.01 ng/ml is associated with long-term mortality after non-cardiac surgery, however, mortality is independent of mechanism. 2017-06-02 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1491571890479287 http://rave.ohiolink.edu/etdc/view?acc_num=case1491571890479287 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Health Care
Health
Medicine
myocardial infarction
myocardial injury
Type 1 MI
Type 2 MI
troponin
peri-operative myocardial injury
non-cardiac surgery
spellingShingle Health Care
Health
Medicine
myocardial infarction
myocardial injury
Type 1 MI
Type 2 MI
troponin
peri-operative myocardial injury
non-cardiac surgery
Reed, Grant William
Associations Between Cardiac Troponin, Mechanism of Myocardial Injury, and Long-Term Mortality After Non-Cardiac Vascular Surgery
author Reed, Grant William
author_facet Reed, Grant William
author_sort Reed, Grant William
title Associations Between Cardiac Troponin, Mechanism of Myocardial Injury, and Long-Term Mortality After Non-Cardiac Vascular Surgery
title_short Associations Between Cardiac Troponin, Mechanism of Myocardial Injury, and Long-Term Mortality After Non-Cardiac Vascular Surgery
title_full Associations Between Cardiac Troponin, Mechanism of Myocardial Injury, and Long-Term Mortality After Non-Cardiac Vascular Surgery
title_fullStr Associations Between Cardiac Troponin, Mechanism of Myocardial Injury, and Long-Term Mortality After Non-Cardiac Vascular Surgery
title_full_unstemmed Associations Between Cardiac Troponin, Mechanism of Myocardial Injury, and Long-Term Mortality After Non-Cardiac Vascular Surgery
title_sort associations between cardiac troponin, mechanism of myocardial injury, and long-term mortality after non-cardiac vascular surgery
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2017
url http://rave.ohiolink.edu/etdc/view?acc_num=case1491571890479287
work_keys_str_mv AT reedgrantwilliam associationsbetweencardiactroponinmechanismofmyocardialinjuryandlongtermmortalityafternoncardiacvascularsurgery
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