Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging

Bibliographic Details
Main Author:	Gao, Ying, Gao
Language:	English
Published:	Case Western Reserve University School of Graduate Studies / OhioLINK 2017
Subjects:	Biomedical Engineering
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=case1475150834919997

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-case14751508349199972021-08-03T06:38:43Z Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging Gao, Ying, Gao Biomedical Engineering Preclinical magnetic resonance imaging (MRI) is critical in the investigation of pathophysiology and therapies. High-field (>= 4.7 T) preclinical MRI scanners have been developed to quantitatively evaluate disease status and the efficacy of novel therapies in a wide variety of rodent models with rigorous validation. High magnetic fields provide increased signal-to-noise ratio (SNR) that can be “traded” for spatial / temporal resolution which is extremely valuable in preclinical imaging. However, high-field preclinical MRI systems also face challenges that affect imaging quality, in which B0 inhomogenieties are a major source of artifacts and entail difficulties of conventional clinical acquisitions in low-field settings applied at high fields. In this work, three MRI techniques were developed for high-field preclinical MRI scanners exploiting a fast imaging with steady-state free precession (FISP) acquisition scheme as a technical core to circumvent the significant off-resonance artifacts on high field MRI scanners. First, a FISP-based Look-Locker T<sub>1</sub> measurement was developed as a non-invasive and sensitive imaging marker to quantitatively assess autosomal recessive polycystic kidney disease (ARPKD) liver disease in the PCK rat model of ARPKD. Second, a rapid and quantitative arterial spin labeling (ASL)-FISP technique was developed for high-field preclinical MRI scanners to provide perfusion-weighted images in less than 2 s with minimal image artifacts and further investigated in neuroimaging. Third, an initial preclinical 7 T MRI implementation of the highly novel magnetic resonance fingerprinting (MRF) methodology was developed and <i>in vivo</i> preclinical MRF results in mouse kidneys and brain tumor models demonstrated an inherent resistance to respiratory motion artifacts as well as sensitivity to known pathology. Overall, FISP-based quantitative MRI techniques developed here will create a wealth of opportunities for preclinical imaging applications and inform future clinical imaging studies. 2017-02-08 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1475150834919997 http://rave.ohiolink.edu/etdc/view?acc_num=case1475150834919997 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Biomedical Engineering
spellingShingle	Biomedical Engineering Gao, Ying, Gao Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging
author	Gao, Ying, Gao
author_facet	Gao, Ying, Gao
author_sort	Gao, Ying, Gao
title	Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging
title_short	Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging
title_full	Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging
title_fullStr	Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging
title_full_unstemmed	Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging
title_sort	development of quantitative fast imaging with steady-state free precession (fisp) techniques for high field preclinical magnetic resonance imaging
publisher	Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate	2017
url	http://rave.ohiolink.edu/etdc/view?acc_num=case1475150834919997
work_keys_str_mv	AT gaoyinggao developmentofquantitativefastimagingwithsteadystatefreeprecessionfisptechniquesforhighfieldpreclinicalmagneticresonanceimaging
_version_	1719440590305755136

Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging

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