S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model

Bibliographic Details
Main Author:	Einisman, Helly J.
Language:	English
Published:	Case Western Reserve University School of Graduate Studies / OhioLINK 2016
Subjects:	Medicine Bronchopulmonary dysplasia S-nitrosoglutathione GSNO GSNO reductase GSNOR GSNOR inhibitor
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=case1464872615

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-case14648726152021-08-03T06:36:52Z S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model Einisman, Helly J. Medicine Bronchopulmonary dysplasia S-nitrosoglutathione GSNO GSNO reductase GSNOR GSNOR inhibitor Bronchopulmonary dysplasia (BPD) is the most common respiratory sequela of prematurity. No strategy successfully reduces its incidence and no treatment solves it absolutely. The activity of S-nitrosoglutathione reductase (GSNOR), the enzyme that degrades GSNO (endogenous bronchodilator), is higher in the lungs of BPD comparing to control mice. In an attempt to find a new target to prevent or treat BPD, we focused on GSNOR in studies using BPD wild-type (WT) mice and GSNOR knockout (KO) mice, in which we also used a GSNOR inhibitor. Major findings were: (1) intrapulmonary bronchioles (IPB) of BPD WT mice were more responsive to methacholine and less responsive to GSNO than WT controls, (2) GSNO elicited equivalent bronchodilation in control and BPD GSNOR KO mice, and (3) pretreatment with a GSNOR inhibitor normalized the bronchodilator efficacy of GSNO in IPB from WT BPD mice. These findings suggest that GSNOR inhibitors are potential therapeutics for BPD. 2016-09-13 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1464872615 http://rave.ohiolink.edu/etdc/view?acc_num=case1464872615 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Medicine Bronchopulmonary dysplasia S-nitrosoglutathione GSNO GSNO reductase GSNOR GSNOR inhibitor
spellingShingle	Medicine Bronchopulmonary dysplasia S-nitrosoglutathione GSNO GSNO reductase GSNOR GSNOR inhibitor Einisman, Helly J. S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model
author	Einisman, Helly J.
author_facet	Einisman, Helly J.
author_sort	Einisman, Helly J.
title	S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model
title_short	S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model
title_full	S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model
title_fullStr	S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model
title_full_unstemmed	S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model
title_sort	s-nitrosoglutathione reductase as a molecular target to prevent bronchopulmonary dysplasia in a murine model
publisher	Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate	2016
url	http://rave.ohiolink.edu/etdc/view?acc_num=case1464872615
work_keys_str_mv	AT einismanhellyj snitrosoglutathionereductaseasamoleculartargettopreventbronchopulmonarydysplasiainamurinemodel
_version_	1719440052549844992

S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model

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