In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant

Bibliographic Details
Main Author:	SHENG, LI
Language:	English
Published:	Case Western Reserve University School of Graduate Studies / OhioLINK 2016
Subjects:	Biomedical Engineering
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=case1446220233

id	ndltd-OhioLink-oai-etd.ohiolink.edu-case1446220233
record_format	oai_dc
spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-case14462202332021-08-03T06:33:30Z In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant SHENG, LI Biomedical Engineering Age-related macular degeneration (AMD) is one of the leading causes of blindness among people above age of 50 in United States. Retinylamine is a promising visual cycle inhibitor in treating dry AMD. As a vitamin A derivative, retinylamine solves the problem of blood-ocular barrier, however, its instability and toxicity both limit its application in AMD treatment. Polylactic acid (PLA) is widely used biodegradable polymer material for drug-loading implant. In this study, a biodegradable PLA-based retinylamine-loading implant is introduced in order to achieve an effective long-time release of retinylamine on dry AMD murine model Abca4-/-Rdh8-/- mice. 2016-01-27 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1446220233 http://rave.ohiolink.edu/etdc/view?acc_num=case1446220233 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Biomedical Engineering
spellingShingle	Biomedical Engineering SHENG, LI In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant
author	SHENG, LI
author_facet	SHENG, LI
author_sort	SHENG, LI
title	In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant
title_short	In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant
title_full	In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant
title_fullStr	In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant
title_full_unstemmed	In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant
title_sort	in vitro and in vivo long-term release of injectable 3-branch pla-retinylamine conjugate implant
publisher	Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate	2016
url	http://rave.ohiolink.edu/etdc/view?acc_num=case1446220233
work_keys_str_mv	AT shengli invitroandinvivolongtermreleaseofinjectable3branchplaretinylamineconjugateimplant
_version_	1719438975928631296

In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant

Similar Items