Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies
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Case Western Reserve University School of Graduate Studies / OhioLINK
2015
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=case1412786849 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-case14127868492021-08-03T06:27:41Z Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies Wright, Katherine L. Biomedical Engineering Magnetic Resonance Imaging Perfusion Dynamic Contrast Enhanced MRI Arterial Spin Labeling Tissue perfusion is an important metric that can provide valuable information for disease diagnosis, treatment planning, and treatment follow-up. MRI can quantify perfusion both with and without Gd-based contrast agents, and can provide spatially-localized perfusion maps. However, these techniques are rarely used in the clinical environment. The works in this thesis focused on providing novel data acquisition and/or reconstruction techniques to overcome limitations in DCE MRI and ASL in order to provide clinically-viable perfusion exams.There are three main projects that will be described in this thesis. First, a simultaneous 3D magnetic resonance angiography and perfusion (MRAP) exam is proposed and is demonstrated in the distal lower extremities. Second, a 3D non-Cartesian parallel imaging method is described and used to achieve a low-dose, 3D, high spatiotemporal resolution renal DCE MRI exam that is acquired without breath-holding. Finally, a novel approach to ASL is proposed using the Magnetic Resonance Fingerprinting framework to simultaneously quantify perfusion, transit time, and tissue T1 in a single, efficient acquisition. 2015-02-09 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1412786849 http://rave.ohiolink.edu/etdc/view?acc_num=case1412786849 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biomedical Engineering Magnetic Resonance Imaging Perfusion Dynamic Contrast Enhanced MRI Arterial Spin Labeling |
| spellingShingle |
Biomedical Engineering Magnetic Resonance Imaging Perfusion Dynamic Contrast Enhanced MRI Arterial Spin Labeling Wright, Katherine L. Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies |
| author |
Wright, Katherine L. |
| author_facet |
Wright, Katherine L. |
| author_sort |
Wright, Katherine L. |
| title |
Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies |
| title_short |
Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies |
| title_full |
Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies |
| title_fullStr |
Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies |
| title_full_unstemmed |
Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies |
| title_sort |
measuring perfusion with magnetic resonance imaging using novel data acquisition and reconstruction strategies |
| publisher |
Case Western Reserve University School of Graduate Studies / OhioLINK |
| publishDate |
2015 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=case1412786849 |
| work_keys_str_mv |
AT wrightkatherinel measuringperfusionwithmagneticresonanceimagingusingnoveldataacquisitionandreconstructionstrategies |
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1719437124140269568 |