The Photophysics and Transport Properties of Non-Covalent Silicon Phthalocyanine Gold Nanoparticle Conjugates

The Photophysics and Transport Properties of Non-Covalent Silicon Phthalocyanine Gold Nanoparticle Conjugates

Bibliographic Details
Main Author: Doane, Tennyson L., III
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2013
Subjects:
Chemistry
Physical Chemistry
Phthalocyanines
Femtosecond Spectroscopy
Nanoparticles
Transport Properties
Drug Delivery
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1365175186
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case13651751862021-08-03T05:21:47Z The Photophysics and Transport Properties of Non-Covalent Silicon Phthalocyanine Gold Nanoparticle Conjugates Doane, Tennyson L., III Chemistry Physical Chemistry Phthalocyanines Femtosecond Spectroscopy Nanoparticles Transport Properties Drug Delivery Nanomedicine has shown great promise for the treatment of a variety of complex diseases including cancer. The use of nanomaterials for non-covalent drug delivery has shown great success in the delivery of photodynamic therapy drugs in animal models, and has great potential as a general delivery vector for hydrophobic drugs. A detailed understanding of what physical forces dictate efficacy in the loading, transport, and delivery of non-covalent drugs is required for optimization and clinical translation. This thesis examines the non-covalent interactions between silicon phthalocyanine 4 (Pc 4) and polyethylene glycol coated gold nanoparticles (PEGylated Au NPs) through photophysics and transport studies. A detailed investigation of Pc 4’s photophysical behavior in water both with and without Au NPs is presented, elucidating the role of intramolecular photoinduced electron transfer and aggregation behavior. Gel electrophoresis studies of PEGylated Au NPs described in this work provide insights on fundamental physical properties of NPs as well as the local environment through which they translate. This thesis provides a “bottom-up” approach to non-covalent drug delivery which will be helpful in translating non-covalent drug delivery to more complex systems. 2013-08-16 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1365175186 http://rave.ohiolink.edu/etdc/view?acc_num=case1365175186 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Chemistry
Physical Chemistry
Phthalocyanines
Femtosecond Spectroscopy
Nanoparticles
Transport Properties
Drug Delivery
spellingShingle Chemistry
Physical Chemistry
Phthalocyanines
Femtosecond Spectroscopy
Nanoparticles
Transport Properties
Drug Delivery

Doane, Tennyson L., III
The Photophysics and Transport Properties of Non-Covalent Silicon Phthalocyanine Gold Nanoparticle Conjugates
author Doane, Tennyson L., III
author_facet Doane, Tennyson L., III
author_sort Doane, Tennyson L., III
title The Photophysics and Transport Properties of Non-Covalent Silicon Phthalocyanine Gold Nanoparticle Conjugates
title_short The Photophysics and Transport Properties of Non-Covalent Silicon Phthalocyanine Gold Nanoparticle Conjugates
title_full The Photophysics and Transport Properties of Non-Covalent Silicon Phthalocyanine Gold Nanoparticle Conjugates
title_fullStr The Photophysics and Transport Properties of Non-Covalent Silicon Phthalocyanine Gold Nanoparticle Conjugates
title_full_unstemmed The Photophysics and Transport Properties of Non-Covalent Silicon Phthalocyanine Gold Nanoparticle Conjugates
title_sort photophysics and transport properties of non-covalent silicon phthalocyanine gold nanoparticle conjugates
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2013
url http://rave.ohiolink.edu/etdc/view?acc_num=case1365175186
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AT doanetennysonliii photophysicsandtransportpropertiesofnoncovalentsiliconphthalocyaninegoldnanoparticleconjugates
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