Acf7 is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin

Acf7 is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin

Bibliographic Details
Main Author: Antonellis, Patrick Joseph
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2013
Subjects:
Biology
Molecular Biology
Cellular Biology
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1365110648
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case13651106482021-08-03T05:21:28Z Acf7 is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin Antonellis, Patrick Joseph Biology Molecular Biology Cellular Biology The hair cell of the inner ear converts mechanical stimuli, such as sound waves, into electrical impulses which are then sent to and interpreted by the brain. Proper organization of the actin and microtubule cytoskeletons is important for establishing the distinct morphology of the hair cell, which is crucial for its function. Here we identify the genes ACF7, MYO9A, and MYO9B are expressed in hair cells, and may be important for hair cell development and function. Through zebrafish transgenesis and indirect labeling of mouse hair cells we show that ACF7 is positioned to integrate the actin and microtubule networks in hair cells. In addition, electron micrographs demonstrate microtubules inserting into the cuticular plate, the ends of which are decorated with proteins that directly link to the F-actin of the cuticular plate. ACF7, which possesses both actin and microtubule binding domains, is a prime candidate to be this linker. 2013-08-16 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1365110648 http://rave.ohiolink.edu/etdc/view?acc_num=case1365110648 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biology
Molecular Biology
Cellular Biology
spellingShingle Biology
Molecular Biology
Cellular Biology
Antonellis, Patrick Joseph
Acf7 is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin
author Antonellis, Patrick Joseph
author_facet Antonellis, Patrick Joseph
author_sort Antonellis, Patrick Joseph
title Acf7 is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin
title_short Acf7 is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin
title_full Acf7 is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin
title_fullStr Acf7 is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin
title_full_unstemmed Acf7 is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin
title_sort acf7 is a hair-bundle antecedent, positioned to integrate cuticular plate actin and somatic tubulin
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2013
url http://rave.ohiolink.edu/etdc/view?acc_num=case1365110648
work_keys_str_mv AT antonellispatrickjoseph acf7isahairbundleantecedentpositionedtointegratecuticularplateactinandsomatictubulin
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