Characterization of the Developmentally Regulated Osteoclast Support Potential of In Vitro Medullary Adipocytes

Bibliographic Details
Main Author:	Holt, Vance Edward Troupe, III
Language:	English
Published:	Case Western Reserve University School of Graduate Studies / OhioLINK 2013
Subjects:	Cellular Biology senile osteoporosis
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=case1364400382

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-case13644003822021-08-03T05:20:49Z Characterization of the Developmentally Regulated Osteoclast Support Potential of In Vitro Medullary Adipocytes Holt, Vance Edward Troupe, III Cellular Biology senile osteoporosis In addition to its widely characterized role in lipid storage and energy metabolism, adipose tissue also has an important role as an endocrine organ. Obesity can alter normal systemic physiologic processes and has been linked to diseases such as cardiovascular disease, diabetes, and hypertension. Most studies have used extramedullary adipose tissue as the primary target for adipose characterization. A less-characterized adipose tissue source is the marrow derived medullary adipose tissue. The medullary adipose tissue depot can increase with age and this increase is associated with a decrease in total bone mass and bone mineral density in both mouse and human subjects. Using a well characterized mesenchymal stem cell (MSC)-derived in vitro medullary adipocyte model, the potential for medullary adipocytes to regulate osteoclast development was tested. Factors important in osteoclast development including RANKL, M-CSF and OPG were expressed by in vitro medullary adipocytes. Furthermore, the expression of these important osteoclast mediators was only observed in a specific population of previously unidentified medullary adipocytes at a particular stage of differentiation. Thus, in vitro medullary adipocytes express osteoclast mediators at a restricted developmental stage within the adipocyte lineage that may play a role in bone remodeling. 2013-08-16 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1364400382 http://rave.ohiolink.edu/etdc/view?acc_num=case1364400382 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center.
collection	NDLTD
language	English
sources	NDLTD
topic	Cellular Biology senile osteoporosis
spellingShingle	Cellular Biology senile osteoporosis Holt, Vance Edward Troupe, III Characterization of the Developmentally Regulated Osteoclast Support Potential of In Vitro Medullary Adipocytes
author	Holt, Vance Edward Troupe, III
author_facet	Holt, Vance Edward Troupe, III
author_sort	Holt, Vance Edward Troupe, III
title	Characterization of the Developmentally Regulated Osteoclast Support Potential of In Vitro Medullary Adipocytes
title_short	Characterization of the Developmentally Regulated Osteoclast Support Potential of In Vitro Medullary Adipocytes
title_full	Characterization of the Developmentally Regulated Osteoclast Support Potential of In Vitro Medullary Adipocytes
title_fullStr	Characterization of the Developmentally Regulated Osteoclast Support Potential of In Vitro Medullary Adipocytes
title_full_unstemmed	Characterization of the Developmentally Regulated Osteoclast Support Potential of In Vitro Medullary Adipocytes
title_sort	characterization of the developmentally regulated osteoclast support potential of in vitro medullary adipocytes
publisher	Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate	2013
url	http://rave.ohiolink.edu/etdc/view?acc_num=case1364400382
work_keys_str_mv	AT holtvanceedwardtroupeiii characterizationofthedevelopmentallyregulatedosteoclastsupportpotentialofinvitromedullaryadipocytes
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Characterization of the Developmentally Regulated Osteoclast Support Potential of In Vitro Medullary Adipocytes

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